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ADAR

GENERAL INFORMATION

Gene name

 ADAR

Gene description

 Adenosine deaminase, RNA-specific

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA003890 , HPA051519 , CAB056157
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003890
HPA051519
CAB056157

GENE INFORMATION

Gene name

 ADAR (HGNC Symbol)

Synonyms

 ADAR1, G1P1, IFI4

Description

 Adenosine deaminase, RNA-specific (HGNC Symbol)

Entrez gene summary

 This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 154582062 - 154627999

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160710 (version 83.38)

Entrez gene

 103

UniProt

 P55265 (UniProt - Evidence at protein level)

neXtProt

 NX_P55265

Antibodypedia

 ADAR antibodies

PROTEIN BROWSER
ADAR-001
ADAR-002
ADAR-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADAR-001
ENSP00000357459
ENST00000368474
P55265 [Direct mapping]
Double-stranded RNA-specific adenosine deaminase
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001649 [osteoblast differentiation]
GO:0001701 [in utero embryonic development]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0002566 [somatic diversification of immune receptors via somatic mutation]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003726 [double-stranded RNA adenosine deaminase activity]
GO:0004000 [adenosine deaminase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006382 [adenosine to inosine editing]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0006606 [protein import into nucleus]
GO:0006611 [protein export from nucleus]
GO:0009615 [response to virus]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016553 [base conversion or substitution editing]
GO:0016556 [mRNA modification]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030218 [erythrocyte differentiation]
GO:0031054 [pre-miRNA processing]
GO:0035196 [production of miRNAs involved in gene silencing by miRNA]
GO:0035280 [miRNA loading onto RISC involved in gene silencing by miRNA]
GO:0035455 [response to interferon-alpha]
GO:0043066 [negative regulation of apoptotic process]
GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation]
GO:0044530 [supraspliceosomal complex]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0051607 [defense response to virus]
GO:0060216 [definitive hemopoiesis]
GO:0060337 [type I interferon signaling pathway]
GO:0060339 [negative regulation of type I interferon-mediated signaling pathway]
GO:0061484 [hematopoietic stem cell homeostasis]
GO:0098586 [cellular response to virus]
GO:1900369 [negative regulation of RNA interference]
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 1226 aa
136.1 kDa 		No 0
ADAR-002
ENSP00000357456
ENST00000368471
P55265 [Direct mapping]
Double-stranded RNA-specific adenosine deaminase
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003726 [double-stranded RNA adenosine deaminase activity]
GO:0004000 [adenosine deaminase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006382 [adenosine to inosine editing]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0006606 [protein import into nucleus]
GO:0006611 [protein export from nucleus]
GO:0009615 [response to virus]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016553 [base conversion or substitution editing]
GO:0016556 [mRNA modification]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031054 [pre-miRNA processing]
GO:0035280 [miRNA loading onto RISC involved in gene silencing by miRNA]
GO:0035455 [response to interferon-alpha]
GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation]
GO:0044530 [supraspliceosomal complex]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0060337 [type I interferon signaling pathway]
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 931 aa
103.6 kDa 		No 0
ADAR-007
ENSP00000431794
ENST00000529168
H0YCK3 [Direct mapping]
Double-stranded RNA-specific adenosine deaminase
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003726 [double-stranded RNA adenosine deaminase activity]
GO:0004000 [adenosine deaminase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006396 [RNA processing]
Show all
 1195 aa
132.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.