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Reliability

Reliability

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Detectable

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ADAR
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    TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ADAR

Gene description

Adenosine deaminase, RNA-specific

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA003890 , HPA051519 , CAB056157
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

ADAR (HGNC Symbol)

Synonyms

ADAR1, G1P1, IFI4

Description

Adenosine deaminase, RNA-specific (HGNC Symbol)

Entrez gene summary

This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

Chromosome

1

Cytoband

q21.3

Chromosome location (bp)

154582062 - 154627999

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160710 (version 83.38)

Entrez gene

103

UniProt

P55265 (UniProt - Evidence at protein level)

neXtProt

NX_P55265

Antibodypedia

ADAR antibodies

PROTEIN BROWSER

ADAR-001
ADAR-002
ADAR-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAR-001
ENSP00000357459
ENST00000368474
P55265 [Direct mapping]
Double-stranded RNA-specific adenosine deaminase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001649 [osteoblast differentiation]
GO:0001701 [in utero embryonic development]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0002566 [somatic diversification of immune receptors via somatic mutation]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003726 [double-stranded RNA adenosine deaminase activity]
GO:0004000 [adenosine deaminase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006382 [adenosine to inosine editing]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0006606 [protein import into nucleus]
GO:0006611 [protein export from nucleus]
GO:0009615 [response to virus]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016553 [base conversion or substitution editing]
GO:0016556 [mRNA modification]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030218 [erythrocyte differentiation]
GO:0031054 [pre-miRNA processing]
GO:0035196 [production of miRNAs involved in gene silencing by miRNA]
GO:0035280 [miRNA loading onto RISC involved in gene silencing by miRNA]
GO:0035455 [response to interferon-alpha]
GO:0043066 [negative regulation of apoptotic process]
GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation]
GO:0044530 [supraspliceosomal complex]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0051607 [defense response to virus]
GO:0060216 [definitive hemopoiesis]
GO:0060337 [type I interferon signaling pathway]
GO:0060339 [negative regulation of type I interferon-mediated signaling pathway]
GO:0061484 [hematopoietic stem cell homeostasis]
GO:0098586 [cellular response to virus]
GO:1900369 [negative regulation of RNA interference]
Show all
1226 aa
136.1 kDa
No 0
ADAR-002
ENSP00000357456
ENST00000368471
P55265 [Direct mapping]
Double-stranded RNA-specific adenosine deaminase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003726 [double-stranded RNA adenosine deaminase activity]
GO:0004000 [adenosine deaminase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006382 [adenosine to inosine editing]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0006606 [protein import into nucleus]
GO:0006611 [protein export from nucleus]
GO:0009615 [response to virus]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016553 [base conversion or substitution editing]
GO:0016556 [mRNA modification]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031054 [pre-miRNA processing]
GO:0035280 [miRNA loading onto RISC involved in gene silencing by miRNA]
GO:0035455 [response to interferon-alpha]
GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation]
GO:0044530 [supraspliceosomal complex]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0060337 [type I interferon signaling pathway]
Show all
931 aa
103.6 kDa
No 0
ADAR-007
ENSP00000431794
ENST00000529168
H0YCK3 [Direct mapping]
Double-stranded RNA-specific adenosine deaminase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003726 [double-stranded RNA adenosine deaminase activity]
GO:0004000 [adenosine deaminase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006396 [RNA processing]
Show all
1195 aa
132.6 kDa
No 0

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