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TONSL

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GENERAL INFORMATION

Gene name

 TONSL

Gene description

 Tonsoku-like, DNA repair protein

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the nuclear bodies.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

Additional location

 In addition localized to the Nuclear bodies (supported)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA024679 , HPA046494
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the nuclear bodies.

Main location

 Nucleoplasm (validated)

Additional location

 Nuclear bodies (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA024679 MCF7 Nucleoplasm
HPA024679 U-2 OS No staining    
HPA024679 U-251 MG Nucleoplasm
HPA046494 MCF7 Nucleoplasm
HPA046494 U-2 OS Nucleoplasm
HPA046494 U-251 MG Nucleoplasm
Nuclear bodies

GENE INFORMATION

Gene name

 TONSL (HGNC Symbol)

Synonyms

 IKBR, NFKBIL2

Description

 Tonsoku-like, DNA repair protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q24.3

Chromosome location (bp)

 144428775 - 144444444

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160949 (version 83.38)

Entrez gene

 4796

UniProt

 Q96HA7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96HA7

Antibodypedia

 TONSL antibodies

PROTEIN BROWSER
TONSL-001
TONSL-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TONSL-001
ENSP00000386239
ENST00000409379
Q96HA7 [Direct mapping]
Tonsoku-like protein
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005662 [DNA replication factor A complex]
GO:0005737 [cytoplasm]
GO:0031297 [replication fork processing]
GO:0035101 [FACT complex]
GO:0042393 [histone binding]
GO:0042555 [MCM complex]
GO:0042994 [cytoplasmic sequestering of transcription factor]
GO:0043596 [nuclear replication fork]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 1378 aa
150.9 kDa 		No 0
TONSL-201
ENSP00000484162
ENST00000613741
A0A087X1F6 [Direct mapping]
Tonsoku-like protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
Show all
 477 aa
52.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.