Expression of TONSL in cancer - Summary - The Human Protein Atlas

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TONSL

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TONSL
Gene description	Tonsoku-like, DNA repair protein
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA024679 , HPA046494
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA024679	HPA046494

GENE INFORMATION
Gene name	TONSL (HGNC Symbol)
Synonyms	IKBR, NFKBIL2
Description	Tonsoku-like, DNA repair protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	144428775 - 144444444
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160949 (version 83.38)
Entrez gene	4796
UniProt	Q96HA7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96HA7
Antibodypedia	TONSL antibodies

PROTEIN BROWSER

TONSL-001	TONSL-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TONSL-001 ENSP00000386239 ENST00000409379	Q96HA7 [Direct mapping] Tonsoku-like protein Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005662 [DNA replication factor A complex] GO:0005737 [cytoplasm] GO:0031297 [replication fork processing] GO:0035101 [FACT complex] GO:0042393 [histone binding] GO:0042555 [MCM complex] GO:0042994 [cytoplasmic sequestering of transcription factor] GO:0043596 [nuclear replication fork] GO:1903507 [negative regulation of nucleic acid-templated transcription] Show all	1378 aa 150.9 kDa	No	0
TONSL-201 ENSP00000484162 ENST00000613741	A0A087X1F6 [Direct mapping] Tonsoku-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	477 aa 52.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.