Tissue expression of TONSL - Summary - The Human Protein Atlas

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TONSL

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TONSL
Gene description	Tonsoku-like, DNA repair protein
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Tissue enhanced (appendix)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA024679 , HPA046494
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (appendix)

GENE INFORMATION
Gene name	TONSL (HGNC Symbol)
Synonyms	IKBR, NFKBIL2
Description	Tonsoku-like, DNA repair protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	144428775 - 144444444
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160949 (version 83.38)
Entrez gene	4796
UniProt	Q96HA7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96HA7
Antibodypedia	TONSL antibodies

PROTEIN BROWSER

TONSL-001	TONSL-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TONSL-001 ENSP00000386239 ENST00000409379	Q96HA7 [Direct mapping] Tonsoku-like protein Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005662 [DNA replication factor A complex] GO:0005737 [cytoplasm] GO:0031297 [replication fork processing] GO:0035101 [FACT complex] GO:0042393 [histone binding] GO:0042555 [MCM complex] GO:0042994 [cytoplasmic sequestering of transcription factor] GO:0043596 [nuclear replication fork] GO:1903507 [negative regulation of nucleic acid-templated transcription] Show all	1378 aa 150.9 kDa	No	0
TONSL-201 ENSP00000484162 ENST00000613741	A0A087X1F6 [Direct mapping] Tonsoku-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	477 aa 52.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.