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Most cancer tissues showed weak to moderate cytoplasmic positivity. Additional membranous positivity was observed in colorectal, ovarian, skin, thyroid and pancreatic cancers. Several melanomas showed strong staining. Several cases of lymphomas, gliomas, liver, testis and renal cancers were negative.
Cancer cells displayed strong cytoplasmic immunoreactivity.
GENE INFORMATION
Gene name
DVL3 (HGNC Symbol)
Synonyms
KIAA0208
Description
Dishevelled segment polarity protein 3 (HGNC Symbol)
Entrez gene summary
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008]
Q92997 [Direct mapping] Segment polarity protein dishevelled homolog DVL-3
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Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001934 [positive regulation of protein phosphorylation] GO:0002020 [protease binding] GO:0003007 [heart morphogenesis] GO:0003148 [outflow tract septum morphogenesis] GO:0005102 [receptor binding] GO:0005109 [frizzled binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0008013 [beta-catenin binding] GO:0016055 [Wnt signaling pathway] GO:0035556 [intracellular signal transduction] GO:0035567 [non-canonical Wnt signaling pathway] GO:0038031 [non-canonical Wnt signaling pathway via JNK cascade] GO:0042493 [response to drug] GO:0043507 [positive regulation of JUN kinase activity] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046982 [protein heterodimerization activity] GO:0060070 [canonical Wnt signaling pathway] GO:0060071 [Wnt signaling pathway, planar cell polarity pathway] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0090103 [cochlea morphogenesis] GO:0090179 [planar cell polarity pathway involved in neural tube closure] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:1903827 [regulation of cellular protein localization]