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DVL3

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GENERAL INFORMATION

Gene name

 DVL3

Gene description

 Dishevelled segment polarity protein 3

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the midbody ring & centrosome. In addition localized to the intermediate filaments.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Midbody ring (approved), Centrosome (approved)

Additional location

 In addition localized to the Intermediate filaments (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by biological definition

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA058265
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the midbody ring & centrosome. In addition localized to the intermediate filaments.

Main location

 Midbody ring (approved), Centrosome (approved)

Additional location

 Intermediate filaments (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA058265 CACO-2 Midbody ring Intensity Intensity
Centrosome Intensity
HPA058265 U-2 OS Intermediate filaments
Midbody ring Intensity Intensity

CELL CYCLE

Summary

 Expression has cell cycle dependency according to biological definition

Intensity variation

 Centrosome

GENE INFORMATION

Gene name

 DVL3 (HGNC Symbol)

Synonyms

 KIAA0208

Description

 Dishevelled segment polarity protein 3 (HGNC Symbol)

Entrez gene summary

 This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q27.1

Chromosome location (bp)

 184155388 - 184173610

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161202 (version 83.38)

Entrez gene

 1857

UniProt

 Q92997 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92997

Antibodypedia

 DVL3 antibodies

PROTEIN BROWSER
DVL3-001
DVL3-002
DVL3-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DVL3-001
ENSP00000316054
ENST00000313143
Q92997 [Direct mapping]
Segment polarity protein dishevelled homolog DVL-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0003007 [heart morphogenesis]
GO:0003148 [outflow tract septum morphogenesis]
GO:0005102 [receptor binding]
GO:0005109 [frizzled binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008013 [beta-catenin binding]
GO:0016055 [Wnt signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0038031 [non-canonical Wnt signaling pathway via JNK cascade]
GO:0042493 [response to drug]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090103 [cochlea morphogenesis]
GO:0090179 [planar cell polarity pathway involved in neural tube closure]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:1903827 [regulation of cellular protein localization]
Show all
 716 aa
78.1 kDa 		No 0
DVL3-002
ENSP00000405885
ENST00000431765
Q92997 [Direct mapping]
Segment polarity protein dishevelled homolog DVL-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0005102 [receptor binding]
GO:0005109 [frizzled binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0008013 [beta-catenin binding]
GO:0016055 [Wnt signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0038031 [non-canonical Wnt signaling pathway via JNK cascade]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090179 [planar cell polarity pathway involved in neural tube closure]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:1903827 [regulation of cellular protein localization]
Show all
 699 aa
76.3 kDa 		No 0
DVL3-005
ENSP00000393849
ENST00000423300
C9K0P9 [Direct mapping]
Segment polarity protein dishevelled homolog DVL-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0090179 [planar cell polarity pathway involved in neural tube closure]
Show all
 220 aa
24.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.