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DVL3

GENERAL INFORMATION

Gene name

 DVL3

Gene description

 Dishevelled segment polarity protein 3

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA058265 , CAB046486
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DVL3 (HGNC Symbol)

Synonyms

 KIAA0208

Description

 Dishevelled segment polarity protein 3 (HGNC Symbol)

Entrez gene summary

 This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q27.1

Chromosome location (bp)

 184155388 - 184173610

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161202 (version 83.38)

Entrez gene

 1857

UniProt

 Q92997 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92997

Antibodypedia

 DVL3 antibodies

PROTEIN BROWSER
DVL3-001
DVL3-002
DVL3-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DVL3-001
ENSP00000316054
ENST00000313143
Q92997 [Direct mapping]
Segment polarity protein dishevelled homolog DVL-3
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0003007 [heart morphogenesis]
GO:0003148 [outflow tract septum morphogenesis]
GO:0005102 [receptor binding]
GO:0005109 [frizzled binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008013 [beta-catenin binding]
GO:0016055 [Wnt signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0038031 [non-canonical Wnt signaling pathway via JNK cascade]
GO:0042493 [response to drug]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090103 [cochlea morphogenesis]
GO:0090179 [planar cell polarity pathway involved in neural tube closure]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:1903827 [regulation of cellular protein localization]
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 716 aa
78.1 kDa 		No 0
DVL3-002
ENSP00000405885
ENST00000431765
Q92997 [Direct mapping]
Segment polarity protein dishevelled homolog DVL-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0005102 [receptor binding]
GO:0005109 [frizzled binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0008013 [beta-catenin binding]
GO:0016055 [Wnt signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0038031 [non-canonical Wnt signaling pathway via JNK cascade]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090179 [planar cell polarity pathway involved in neural tube closure]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:1903827 [regulation of cellular protein localization]
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 699 aa
76.3 kDa 		No 0
DVL3-005
ENSP00000393849
ENST00000423300
C9K0P9 [Direct mapping]
Segment polarity protein dishevelled homolog DVL-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0090179 [planar cell polarity pathway involved in neural tube closure]
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 220 aa
24.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.