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SDC3

GENERAL INFORMATION

Gene name

 SDC3

Gene description

 Syndecan 3

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA017087 , CAB025786
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SDC3 (HGNC Symbol)

Synonyms

 N-syndecan, SYND3

Description

 Syndecan 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the syndecan proteoglycan family. It may play a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. Allelic variants of this gene have been associated with obesity. [provided by RefSeq, Oct 2009]

Chromosome

 1

Cytoband

 p35.2

Chromosome location (bp)

 30869467 - 30908761

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162512 (version 83.38)

Entrez gene

 9672

UniProt

 O75056 (UniProt - Evidence at protein level)

neXtProt

 NX_O75056

Antibodypedia

 SDC3 antibodies

PROTEIN BROWSER
SDC3-001
SDC3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SDC3-001
ENSP00000338346
ENST00000336798
D3DPN2 [Direct mapping]
Syndecan
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
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GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
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 384 aa
39.6 kDa 		No 1
SDC3-002
ENSP00000344468
ENST00000339394
O75056 [Direct mapping]
Syndecan-3
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0005515 [protein binding]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0007155 [cell adhesion]
GO:0007603 [phototransduction, visible light]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030424 [axon]
GO:0043005 [neuron projection]
GO:0043202 [lysosomal lumen]
GO:0043234 [protein complex]
GO:0044281 [small molecule metabolic process]
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 442 aa
45.5 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.