Cell atlas - PIGR - The Human Protein Atlas

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PIGR

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli
	Nucleus

Human cell
	Cytosol
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PIGR
Gene description	Polymeric immunoglobulin receptor
Protein class	Cancer-related genes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the nucleoli & cytosol.
RNA cell category	Cell line enriched (EFO-21)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (uncertain)
Additional location	In addition localized to the Nucleoli (uncertain), Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 2 antibodies. HPA006154 , HPA012012
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (EFO-21) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the nucleoli & cytosol.

Main location

Nucleus (uncertain)

Additional location

Nucleoli (uncertain), Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA012012	A-431	No staining
	HPA012012	U-2 OS	No staining
	HPA012012	U-251 MG	Nucleoplasm
	HPA006154	A-431	Nucleus
			Nucleoli
			Cytosol
	HPA006154	U-2 OS	Cytosol
	HPA006154	U-251 MG	No staining

GENE INFORMATION
Gene name	PIGR
Synonyms
Description	Polymeric immunoglobulin receptor (HGNC Symbol)
Entrez gene summary	This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	206928518 - 206946466
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162896 (version 83.38)
Entrez gene	5284
UniProt	P01833 (UniProt - Evidence at protein level)
neXtProt	NX_P01833
Antibodypedia	PIGR antibodies

PROTEIN BROWSER

PIGR-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIGR-001 ENSP00000348888 ENST00000356495	P01833 [Direct mapping] Polymeric immunoglobulin receptor Secretory component Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001580 [detection of chemical stimulus involved in sensory perception of bitter taste] GO:0001792 [polymeric immunoglobulin receptor activity] GO:0001895 [retina homeostasis] GO:0002415 [immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0038093 [Fc receptor signaling pathway] GO:0043113 [receptor clustering] GO:0043235 [receptor complex] GO:0070062 [extracellular exosome] Show all	764 aa 83.3 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.