Expression of PIGR in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PIGR
Gene description	Polymeric immunoglobulin receptor
Protein class	Cancer-related genes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (colorectal cancer)
HPA (cell line):	Cell line enriched (EFO-21)
HPA (normal tissue):	Tissue enhanced (colon, duodenum)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in gastrointestinal mucosa, kidney, gall- and urinary bladder with extracellular positivity in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA006154 , HPA012012 , CAB009454
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable), renal cancer (favourable) and endometrial cancer (favourable).
Breast cancer p<0.001 Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (colorectal cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA006154	HPA012012	CAB009454

GENE INFORMATION
Gene name	PIGR
Synonyms
Description	Polymeric immunoglobulin receptor (HGNC Symbol)
Entrez gene summary	This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	206928518 - 206946466
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162896 (version 83.38)
Entrez gene	5284
UniProt	P01833 (UniProt - Evidence at protein level)
neXtProt	NX_P01833
Antibodypedia	PIGR antibodies

PROTEIN BROWSER

PIGR-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIGR-001 ENSP00000348888 ENST00000356495	P01833 [Direct mapping] Polymeric immunoglobulin receptor Secretory component Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001580 [detection of chemical stimulus involved in sensory perception of bitter taste] GO:0001792 [polymeric immunoglobulin receptor activity] GO:0001895 [retina homeostasis] GO:0002415 [immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0038093 [Fc receptor signaling pathway] GO:0043113 [receptor clustering] GO:0043235 [receptor complex] GO:0070062 [extracellular exosome] Show all	764 aa 83.3 kDa	Yes	1