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CDC42EP3

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GENERAL INFORMATION

Gene name

 CDC42EP3

Gene description

 CDC42 effector protein (Rho GTPase binding) 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoli & cytosol.

RNA cell category

 Cell line enhanced (LHCN-M2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA034986
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (LHCN-M2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoli & cytosol.

Main location

 Nucleoli (approved), Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA034986 A-431 Nucleoli fibrillar center
Cytosol
HPA034986 U-2 OS Nucleoli fibrillar center
Cytosol
HPA034986 U-251 MG Nucleoli
Cytosol

GENE INFORMATION

Gene name

 CDC42EP3 (HGNC Symbol)

Synonyms

 BORG2, CEP3, UB1

Description

 CDC42 effector protein (Rho GTPase binding) 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Chromosome

 2

Cytoband

 p22.2

Chromosome location (bp)

 37641882 - 37738468

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163171 (version 83.38)

Entrez gene

 10602

UniProt

 Q9UKI2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKI2

Antibodypedia

 CDC42EP3 antibodies

PROTEIN BROWSER
CDC42EP3-001
CDC42EP3-002
CDC42EP3-005
CDC42EP3-006
CDC42EP3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC42EP3-001
ENSP00000295324
ENST00000295324
Q9UKI2 [Direct mapping]
Cdc42 effector protein 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005519 [cytoskeletal regulatory protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0012505 [endomembrane system]
GO:0015629 [actin cytoskeleton]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0043547 [positive regulation of GTPase activity]
Show all
 254 aa
27.7 kDa 		No 0
CDC42EP3-002
ENSP00000403298
ENST00000457889
C9JEZ4 [Direct mapping]
Cdc42 effector protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0043547 [positive regulation of GTPase activity]
Show all
 216 aa
23.6 kDa 		No 0
CDC42EP3-005
ENSP00000409147
ENST00000422687
C9JKW5 [Direct mapping]
Cdc42 effector protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0043547 [positive regulation of GTPase activity]
Show all
 14 aa
1.5 kDa 		No 0
CDC42EP3-006
ENSP00000398062
ENST00000453555
C9J7F7 [Direct mapping]
Cdc42 effector protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0043547 [positive regulation of GTPase activity]
Show all
 35 aa
3.9 kDa 		No 0
CDC42EP3-201
ENSP00000480549
ENST00000611976
Q9UKI2 [Direct mapping]
Cdc42 effector protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005519 [cytoskeletal regulatory protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0012505 [endomembrane system]
GO:0015629 [actin cytoskeleton]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0043547 [positive regulation of GTPase activity]
Show all
 254 aa
27.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.