Fields »
ABOUT
HELP
BLOG
CDC42EP3

GENERAL INFORMATION

Gene name

 CDC42EP3

Gene description

 CDC42 effector protein (Rho GTPase binding) 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (LHCN-M2)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with additional membranous expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA034986
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA034986

GENE INFORMATION

Gene name

 CDC42EP3 (HGNC Symbol)

Synonyms

 BORG2, CEP3, UB1

Description

 CDC42 effector protein (Rho GTPase binding) 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Chromosome

 2

Cytoband

 p22.2

Chromosome location (bp)

 37641882 - 37738468

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163171 (version 83.38)

Entrez gene

 10602

UniProt

 Q9UKI2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKI2

Antibodypedia

 CDC42EP3 antibodies

PROTEIN BROWSER
CDC42EP3-001
CDC42EP3-002
CDC42EP3-005
CDC42EP3-006
CDC42EP3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC42EP3-001
ENSP00000295324
ENST00000295324
Q9UKI2 [Direct mapping]
Cdc42 effector protein 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005519 [cytoskeletal regulatory protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0012505 [endomembrane system]
GO:0015629 [actin cytoskeleton]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0043547 [positive regulation of GTPase activity]
Show all
 254 aa
27.7 kDa 		No 0
CDC42EP3-002
ENSP00000403298
ENST00000457889
C9JEZ4 [Direct mapping]
Cdc42 effector protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0043547 [positive regulation of GTPase activity]
Show all
 216 aa
23.6 kDa 		No 0
CDC42EP3-005
ENSP00000409147
ENST00000422687
C9JKW5 [Direct mapping]
Cdc42 effector protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0043547 [positive regulation of GTPase activity]
Show all
 14 aa
1.5 kDa 		No 0
CDC42EP3-006
ENSP00000398062
ENST00000453555
C9J7F7 [Direct mapping]
Cdc42 effector protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0043547 [positive regulation of GTPase activity]
Show all
 35 aa
3.9 kDa 		No 0
CDC42EP3-201
ENSP00000480549
ENST00000611976
Q9UKI2 [Direct mapping]
Cdc42 effector protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005519 [cytoskeletal regulatory protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0012505 [endomembrane system]
GO:0015629 [actin cytoskeleton]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0043547 [positive regulation of GTPase activity]
Show all
 254 aa
27.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.