Cell atlas - IVL - The Human Protein Atlas

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IVL

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Cytosol
	Nuclear bodies

Human cell
	Centrosome
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	IVL
Gene description	Involucrin
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the centrosome & nuclear bodies.
RNA cell category	Group enriched (HaCaT, SK-BR-3, RT4)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Additional location	In addition localized to the Nuclear bodies (approved), Centrosome (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. CAB002243 , HPA055211
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HaCaT, SK-BR-3, RT4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the centrosome & nuclear bodies.

Main location

Cytosol (supported)

Additional location

Nuclear bodies (approved), Centrosome (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
CAB002243	A-431	Cytosol	Intensity
CAB002243	U-251 MG	No staining
HPA055211	HaCaT	Nuclear bodies
		Centrosome
		Cytosol	Intensity
HPA055211	RT4	Cytosol	Intensity
HPA055211	U-2 OS	No staining

GENE INFORMATION
Gene name	IVL
Synonyms
Description	Involucrin (HGNC Symbol)
Entrez gene summary	Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	152908545 - 152911886
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163207 (version 83.38)
Entrez gene	3713
UniProt	P07476 (UniProt - Evidence at protein level)
neXtProt	NX_P07476
Antibodypedia	IVL antibodies

PROTEIN BROWSER

IVL-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IVL-001 ENSP00000357753 ENST00000368764	P07476 [Direct mapping] Involucrin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001533 [cornified envelope] GO:0005198 [structural molecule activity] GO:0005737 [cytoplasm] GO:0010224 [response to UV-B] GO:0018149 [peptide cross-linking] GO:0018153 [isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine] GO:0030216 [keratinocyte differentiation] GO:0030674 [protein binding, bridging] GO:0031424 [keratinization] GO:0070062 [extracellular exosome] Show all	585 aa 68.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.