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IVL

GENERAL INFORMATION

Gene name

 IVL

Gene description

 Involucrin

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (esophagus, skin)
GTEx:Group enriched (cervix, uterine, esophagus, salivary gland, skin, vagina)
FANTOM5:Group enriched (cervix, uterine, esophagus, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in squamous epithelia.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Pending retesting.

Reliability score

 Supported based on 2 antibodies.
HPA055211 , CAB002243
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Oral mucosa

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cervix, uterine, esophagus, salivary gland, skin, vagina)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cervix, uterine, esophagus, tonsil)

GENE INFORMATION

Gene name

 IVL

Synonyms

Description

 Involucrin (HGNC Symbol)

Entrez gene summary

 Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 152908545 - 152911886

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163207 (version 83.38)

Entrez gene

 3713

UniProt

 P07476 (UniProt - Evidence at protein level)

neXtProt

 NX_P07476

Antibodypedia

 IVL antibodies

PROTEIN BROWSER
IVL-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IVL-001
ENSP00000357753
ENST00000368764
P07476 [Direct mapping]
Involucrin
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001533 [cornified envelope]
GO:0005198 [structural molecule activity]
GO:0005737 [cytoplasm]
GO:0010224 [response to UV-B]
GO:0018149 [peptide cross-linking]
GO:0018153 [isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine]
GO:0030216 [keratinocyte differentiation]
GO:0030674 [protein binding, bridging]
GO:0031424 [keratinization]
GO:0070062 [extracellular exosome]
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 585 aa
68.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.