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IVL

GENERAL INFORMATION

Gene name

 IVL

Gene description

 Involucrin

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (cervical cancer, head and neck cancer, melanoma, urothelial cancer)
HPA (cell line):Group enriched (HaCaT, RT4, SK-BR-3)
HPA (normal tissue):Group enriched (esophagus, skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in squamous epithelia.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Pending retesting.

Reliability score

 Supported based on 2 antibodies.
HPA055211 , CAB002243
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (cervical cancer, head and neck cancer, melanoma, urothelial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA055211
CAB002243

GENE INFORMATION

Gene name

 IVL

Synonyms

Description

 Involucrin (HGNC Symbol)

Entrez gene summary

 Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 152908545 - 152911886

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163207 (version 83.38)

Entrez gene

 3713

UniProt

 P07476 (UniProt - Evidence at protein level)

neXtProt

 NX_P07476

Antibodypedia

 IVL antibodies

PROTEIN BROWSER
IVL-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IVL-001
ENSP00000357753
ENST00000368764
P07476 [Direct mapping]
Involucrin
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001533 [cornified envelope]
GO:0005198 [structural molecule activity]
GO:0005737 [cytoplasm]
GO:0010224 [response to UV-B]
GO:0018149 [peptide cross-linking]
GO:0018153 [isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine]
GO:0030216 [keratinocyte differentiation]
GO:0030674 [protein binding, bridging]
GO:0031424 [keratinization]
GO:0070062 [extracellular exosome]
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 585 aa
68.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.