Tissue expression of AIM2 - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

AIM2

TISSUE

premium

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	AIM2
Gene description	Absent in melanoma 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (lymph node, spleen, tonsil)
GTEx:	Group enriched (pituitary gland, small intestine, spleen)
FANTOM5:	Group enriched (appendix, lymph node, pituitary gland, spleen, tonsil)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA031365
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lymph node, spleen, tonsil)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (pituitary gland, small intestine, spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (appendix, lymph node, pituitary gland, spleen, tonsil)

GENE INFORMATION
Gene name	AIM2 (HGNC Symbol)
Synonyms	PYHIN4
Description	Absent in melanoma 2 (HGNC Symbol)
Entrez gene summary	AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband
Chromosome location (bp)	159062484 - 159147096
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163568 (version 83.38)
Entrez gene	9447
UniProt	O14862 (UniProt - Evidence at protein level)
neXtProt	NX_O14862
Antibodypedia	AIM2 antibodies

PROTEIN BROWSER

AIM2-001	AIM2-004	AIM2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AIM2-001 ENSP00000357112 ENST00000368130	O14862 [Direct mapping] Interferon-inducible protein AIM2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002218 [activation of innate immune response] GO:0002230 [positive regulation of defense response to virus by host] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032461 [positive regulation of protein oligomerization] GO:0032731 [positive regulation of interleukin-1 beta production] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0035458 [cellular response to interferon-beta] GO:0035690 [cellular response to drug] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0042802 [identical protein binding] GO:0045087 [innate immune response] GO:0050702 [interleukin-1 beta secretion] GO:0050718 [positive regulation of interleukin-1 beta secretion] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0070269 [pyroptosis] GO:0097169 [AIM2 inflammasome complex] GO:2001056 [positive regulation of cysteine-type endopeptidase activity] Show all	343 aa 39 kDa	No	0
AIM2-004 ENSP00000357111 ENST00000368129	Q5T3W0 [Direct mapping] Interferon-inducible protein AIM2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		167 aa 19.1 kDa	No	0
AIM2-201 ENSP00000483485 ENST00000612470	A0A087X0L4 [Direct mapping] Interferon-inducible protein AIM2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		355 aa 40.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.