Expression of ALB in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ALB
Gene description	Albumin
Protein class	Cancer-related genes Candidate cardiovascular disease genes Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enriched (Hep G2)
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Positivity in plasma and extracellular material with additional cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 3 antibodies. HPA031024 , HPA031025 , CAB006262
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PROGNOSTIC SUMMARY
Prognostic marker in stomach cancer (unfavourable).
Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA031024	HPA031025	CAB006262

GENE INFORMATION
Gene name	ALB
Synonyms
Description	Albumin (HGNC Symbol)
Entrez gene summary	Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Albumin is a globular unglycosylated serum protein of molecular weight 65,000. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	73397114 - 73421412
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163631 (version 83.38)
Entrez gene	213
UniProt	P02768 (UniProt - Evidence at protein level)
neXtProt	NX_P02768
Antibodypedia	ALB antibodies

PROTEIN BROWSER

ALB-001	ALB-002	ALB-005	ALB-009	ALB-011	ALB-013	ALB-016	ALB-201	ALB-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALB-001 ENSP00000295897 ENST00000295897	P02768 [Direct mapping] Serum albumin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001895 [retina homeostasis] GO:0002576 [platelet degranulation] GO:0003677 [DNA binding] GO:0005504 [fatty acid binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006810 [transport] GO:0006898 [receptor-mediated endocytosis] GO:0007584 [response to nutrient] GO:0007596 [blood coagulation] GO:0008144 [drug binding] GO:0008206 [bile acid metabolic process] GO:0008270 [zinc ion binding] GO:0009267 [cellular response to starvation] GO:0010033 [response to organic substance] GO:0015643 [toxic substance binding] GO:0015721 [bile acid and bile salt transport] GO:0016209 [antioxidant activity] GO:0019825 [oxygen binding] GO:0019836 [hemolysis by symbiont of host erythrocytes] GO:0019899 [enzyme binding] GO:0030168 [platelet activation] GO:0030170 [pyridoxal phosphate binding] GO:0031093 [platelet alpha granule lumen] GO:0042157 [lipoprotein metabolic process] GO:0043066 [negative regulation of apoptotic process] GO:0043069 [negative regulation of programmed cell death] GO:0043209 [myelin sheath] GO:0043234 [protein complex] GO:0043252 [sodium-independent organic anion transport] GO:0044281 [small molecule metabolic process] GO:0046010 [positive regulation of circadian sleep/wake cycle, non-REM sleep] GO:0046689 [response to mercury ion] GO:0051087 [chaperone binding] GO:0051659 [maintenance of mitochondrion location] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0070541 [response to platinum ion] GO:0072562 [blood microparticle] Show all	609 aa 69.4 kDa	Yes	0
ALB-002 ENSP00000384695 ENST00000401494	B7WNR0 [Direct mapping] Serum albumin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0006810 [transport] Show all	494 aa 56.2 kDa	Yes	0
ALB-005 ENSP00000392541 ENST00000441319	H7C013 [Direct mapping] Serum albumin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0006810 [transport] Show all	197 aa 22.9 kDa	No	0
ALB-009 ENSP00000401820 ENST00000415165	C9JKR2 [Direct mapping] Albumin, isoform CRA_k; Serum albumin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0006810 [transport] Show all	417 aa 47.3 kDa	Yes	0
ALB-011 ENSP00000421027 ENST00000503124	D6RHD5 [Direct mapping] Serum albumin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0006810 [transport] Show all	459 aa 52.1 kDa	No	0
ALB-013 ENSP00000422784 ENST00000509063	A0A0C4DGB6 [Direct mapping] Serum albumin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0006810 [transport] Show all	604 aa 69.2 kDa	Yes	0
ALB-016 ENSP00000426179 ENST00000511370	H0YA55 [Direct mapping] Serum albumin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0006810 [transport] Show all	454 aa 51.5 kDa	No	0
ALB-201 ENSP00000483421 ENST00000621085	P02768 [Direct mapping] Serum albumin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001895 [retina homeostasis] GO:0002576 [platelet degranulation] GO:0003677 [DNA binding] GO:0005504 [fatty acid binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0006810 [transport] GO:0006898 [receptor-mediated endocytosis] GO:0007596 [blood coagulation] GO:0008144 [drug binding] GO:0008206 [bile acid metabolic process] GO:0009267 [cellular response to starvation] GO:0015643 [toxic substance binding] GO:0015721 [bile acid and bile salt transport] GO:0016209 [antioxidant activity] GO:0019825 [oxygen binding] GO:0019836 [hemolysis by symbiont of host erythrocytes] GO:0030168 [platelet activation] GO:0030170 [pyridoxal phosphate binding] GO:0031093 [platelet alpha granule lumen] GO:0042157 [lipoprotein metabolic process] GO:0043066 [negative regulation of apoptotic process] GO:0043069 [negative regulation of programmed cell death] GO:0043234 [protein complex] GO:0043252 [sodium-independent organic anion transport] GO:0044281 [small molecule metabolic process] GO:0051087 [chaperone binding] GO:0051659 [maintenance of mitochondrion location] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	396 aa 45.2 kDa	Yes	0
ALB-202 ENSP00000480485 ENST00000621628	A0A087WWT3 [Direct mapping] Serum albumin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0006810 [transport] Show all	396 aa 45.1 kDa	Yes	0