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Gene name

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Chromosome

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In atlas

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Reliability

Reliability

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Method

Validation

Method

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Searches

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Cell line

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Cancer

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Detectable

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Detectable

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ALB
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    TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ALB

Gene description

Albumin

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression

Positivity in plasma and extracellular material with additional cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 3 antibodies.
HPA031024 , HPA031025 , CAB006262
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

ALB

Synonyms

Description

Albumin (HGNC Symbol)

Entrez gene summary

Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Albumin is a globular unglycosylated serum protein of molecular weight 65,000. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q13.3

Chromosome location (bp)

73397114 - 73421412

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163631 (version 83.38)

Entrez gene

213

UniProt

P02768 (UniProt - Evidence at protein level)

neXtProt

NX_P02768

Antibodypedia

ALB antibodies

PROTEIN BROWSER

ALB-001
ALB-002
ALB-005
ALB-009
ALB-011
ALB-013
ALB-016
ALB-201
ALB-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ALB-001
ENSP00000295897
ENST00000295897
P02768 [Direct mapping]
Serum albumin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001895 [retina homeostasis]
GO:0002576 [platelet degranulation]
GO:0003677 [DNA binding]
GO:0005504 [fatty acid binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006810 [transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007584 [response to nutrient]
GO:0007596 [blood coagulation]
GO:0008144 [drug binding]
GO:0008206 [bile acid metabolic process]
GO:0008270 [zinc ion binding]
GO:0009267 [cellular response to starvation]
GO:0010033 [response to organic substance]
GO:0015643 [toxic substance binding]
GO:0015721 [bile acid and bile salt transport]
GO:0016209 [antioxidant activity]
GO:0019825 [oxygen binding]
GO:0019836 [hemolysis by symbiont of host erythrocytes]
GO:0019899 [enzyme binding]
GO:0030168 [platelet activation]
GO:0030170 [pyridoxal phosphate binding]
GO:0031093 [platelet alpha granule lumen]
GO:0042157 [lipoprotein metabolic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043069 [negative regulation of programmed cell death]
GO:0043209 [myelin sheath]
GO:0043234 [protein complex]
GO:0043252 [sodium-independent organic anion transport]
GO:0044281 [small molecule metabolic process]
GO:0046010 [positive regulation of circadian sleep/wake cycle, non-REM sleep]
GO:0046689 [response to mercury ion]
GO:0051087 [chaperone binding]
GO:0051659 [maintenance of mitochondrion location]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070541 [response to platinum ion]
GO:0072562 [blood microparticle]
Show all
609 aa
69.4 kDa
Yes 0
ALB-002
ENSP00000384695
ENST00000401494
B7WNR0 [Direct mapping]
Serum albumin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0006810 [transport]
Show all
494 aa
56.2 kDa
Yes 0
ALB-005
ENSP00000392541
ENST00000441319
H7C013 [Direct mapping]
Serum albumin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0006810 [transport]
Show all
197 aa
22.9 kDa
No 0
ALB-009
ENSP00000401820
ENST00000415165
C9JKR2 [Direct mapping]
Albumin, isoform CRA_k; Serum albumin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0006810 [transport]
Show all
417 aa
47.3 kDa
Yes 0
ALB-011
ENSP00000421027
ENST00000503124
D6RHD5 [Direct mapping]
Serum albumin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0006810 [transport]
Show all
459 aa
52.1 kDa
No 0
ALB-013
ENSP00000422784
ENST00000509063
A0A0C4DGB6 [Direct mapping]
Serum albumin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0006810 [transport]
Show all
604 aa
69.2 kDa
Yes 0
ALB-016
ENSP00000426179
ENST00000511370
H0YA55 [Direct mapping]
Serum albumin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0006810 [transport]
Show all
454 aa
51.5 kDa
No 0
ALB-201
ENSP00000483421
ENST00000621085
P02768 [Direct mapping]
Serum albumin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001895 [retina homeostasis]
GO:0002576 [platelet degranulation]
GO:0003677 [DNA binding]
GO:0005504 [fatty acid binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0006810 [transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007596 [blood coagulation]
GO:0008144 [drug binding]
GO:0008206 [bile acid metabolic process]
GO:0009267 [cellular response to starvation]
GO:0015643 [toxic substance binding]
GO:0015721 [bile acid and bile salt transport]
GO:0016209 [antioxidant activity]
GO:0019825 [oxygen binding]
GO:0019836 [hemolysis by symbiont of host erythrocytes]
GO:0030168 [platelet activation]
GO:0030170 [pyridoxal phosphate binding]
GO:0031093 [platelet alpha granule lumen]
GO:0042157 [lipoprotein metabolic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043069 [negative regulation of programmed cell death]
GO:0043234 [protein complex]
GO:0043252 [sodium-independent organic anion transport]
GO:0044281 [small molecule metabolic process]
GO:0051087 [chaperone binding]
GO:0051659 [maintenance of mitochondrion location]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
Show all
396 aa
45.2 kDa
Yes 0
ALB-202
ENSP00000480485
ENST00000621628
A0A087WWT3 [Direct mapping]
Serum albumin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0006810 [transport]
Show all
396 aa
45.1 kDa
Yes 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.