Fields »
ABOUT
HELP
BLOG
ALB

GENERAL INFORMATION

Gene name

 ALB

Gene description

 Albumin

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression

 Positivity in plasma and extracellular material with additional cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 3 antibodies.
HPA031024 , HPA031025 , CAB006262
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

 ALB

Synonyms

Description

 Albumin (HGNC Symbol)

Entrez gene summary

 Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Albumin is a globular unglycosylated serum protein of molecular weight 65,000. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q13.3

Chromosome location (bp)

 73397114 - 73421412

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163631 (version 83.38)

Entrez gene

 213

UniProt

 P02768 (UniProt - Evidence at protein level)

neXtProt

 NX_P02768

Antibodypedia

 ALB antibodies

PROTEIN BROWSER
ALB-001
ALB-002
ALB-005
ALB-009
ALB-011
ALB-013
ALB-016
ALB-201
ALB-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALB-001
ENSP00000295897
ENST00000295897
P02768 [Direct mapping]
Serum albumin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001895 [retina homeostasis]
GO:0002576 [platelet degranulation]
GO:0003677 [DNA binding]
GO:0005504 [fatty acid binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006810 [transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007584 [response to nutrient]
GO:0007596 [blood coagulation]
GO:0008144 [drug binding]
GO:0008206 [bile acid metabolic process]
GO:0008270 [zinc ion binding]
GO:0009267 [cellular response to starvation]
GO:0010033 [response to organic substance]
GO:0015643 [toxic substance binding]
GO:0015721 [bile acid and bile salt transport]
GO:0016209 [antioxidant activity]
GO:0019825 [oxygen binding]
GO:0019836 [hemolysis by symbiont of host erythrocytes]
GO:0019899 [enzyme binding]
GO:0030168 [platelet activation]
GO:0030170 [pyridoxal phosphate binding]
GO:0031093 [platelet alpha granule lumen]
GO:0042157 [lipoprotein metabolic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043069 [negative regulation of programmed cell death]
GO:0043209 [myelin sheath]
GO:0043234 [protein complex]
GO:0043252 [sodium-independent organic anion transport]
GO:0044281 [small molecule metabolic process]
GO:0046010 [positive regulation of circadian sleep/wake cycle, non-REM sleep]
GO:0046689 [response to mercury ion]
GO:0051087 [chaperone binding]
GO:0051659 [maintenance of mitochondrion location]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070541 [response to platinum ion]
GO:0072562 [blood microparticle]
Show all
 609 aa
69.4 kDa 		Yes 0
ALB-002
ENSP00000384695
ENST00000401494
B7WNR0 [Direct mapping]
Serum albumin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0006810 [transport]
Show all
 494 aa
56.2 kDa 		Yes 0
ALB-005
ENSP00000392541
ENST00000441319
H7C013 [Direct mapping]
Serum albumin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0006810 [transport]
Show all
 197 aa
22.9 kDa 		No 0
ALB-009
ENSP00000401820
ENST00000415165
C9JKR2 [Direct mapping]
Albumin, isoform CRA_k; Serum albumin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0006810 [transport]
Show all
 417 aa
47.3 kDa 		Yes 0
ALB-011
ENSP00000421027
ENST00000503124
D6RHD5 [Direct mapping]
Serum albumin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0006810 [transport]
Show all
 459 aa
52.1 kDa 		No 0
ALB-013
ENSP00000422784
ENST00000509063
A0A0C4DGB6 [Direct mapping]
Serum albumin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0006810 [transport]
Show all
 604 aa
69.2 kDa 		Yes 0
ALB-016
ENSP00000426179
ENST00000511370
H0YA55 [Direct mapping]
Serum albumin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0006810 [transport]
Show all
 454 aa
51.5 kDa 		No 0
ALB-201
ENSP00000483421
ENST00000621085
P02768 [Direct mapping]
Serum albumin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001895 [retina homeostasis]
GO:0002576 [platelet degranulation]
GO:0003677 [DNA binding]
GO:0005504 [fatty acid binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0006810 [transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007596 [blood coagulation]
GO:0008144 [drug binding]
GO:0008206 [bile acid metabolic process]
GO:0009267 [cellular response to starvation]
GO:0015643 [toxic substance binding]
GO:0015721 [bile acid and bile salt transport]
GO:0016209 [antioxidant activity]
GO:0019825 [oxygen binding]
GO:0019836 [hemolysis by symbiont of host erythrocytes]
GO:0030168 [platelet activation]
GO:0030170 [pyridoxal phosphate binding]
GO:0031093 [platelet alpha granule lumen]
GO:0042157 [lipoprotein metabolic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043069 [negative regulation of programmed cell death]
GO:0043234 [protein complex]
GO:0043252 [sodium-independent organic anion transport]
GO:0044281 [small molecule metabolic process]
GO:0051087 [chaperone binding]
GO:0051659 [maintenance of mitochondrion location]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
Show all
 396 aa
45.2 kDa 		Yes 0
ALB-202
ENSP00000480485
ENST00000621628
A0A087WWT3 [Direct mapping]
Serum albumin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0006810 [transport]
Show all
 396 aa
45.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.