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POLR2H

GENERAL INFORMATION

Gene name

 POLR2H

Gene description

 Polymerase (RNA) II (DNA directed) polypeptide H

Protein class

 Predicted intracellular proteins
RNA polymerase related proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA037745
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037745

GENE INFORMATION

Gene name

 POLR2H (HGNC Symbol)

Synonyms

 RPB8

Description

 Polymerase (RNA) II (DNA directed) polypeptide H (HGNC Symbol)

Entrez gene summary

 The three eukaryotic RNA polymerases are complex multisubunit enzymes that play a central role in the transcription of nuclear genes. This gene encodes an essential and highly conserved subunit of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Chromosome

 3

Cytoband

 q27.1

Chromosome location (bp)

 184361718 - 184368596

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163882 (version 83.38)

Entrez gene

 5437

UniProt

 P52434 (UniProt - Evidence at protein level)

neXtProt

 NX_P52434

Antibodypedia

 POLR2H antibodies

PROTEIN BROWSER
POLR2H-001
POLR2H-002
POLR2H-003
POLR2H-005
POLR2H-006
POLR2H-007
POLR2H-008
POLR2H-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLR2H-001
ENSP00000392913
ENST00000456318
P52434 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC3
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0031047 [gene silencing by RNA]
GO:0032481 [positive regulation of type I interferon production]
GO:0034587 [piRNA metabolic process]
GO:0035019 [somatic stem cell population maintenance]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045087 [innate immune response]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0050434 [positive regulation of viral transcription]
Show all
 150 aa
17.1 kDa 		No 0
POLR2H-002
ENSP00000403728
ENST00000412877
C9JJJ9 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC3
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 12 aa
1.4 kDa 		No 0
POLR2H-003
ENSP00000398622
ENST00000438240
P52434 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC3
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0031047 [gene silencing by RNA]
GO:0032481 [positive regulation of type I interferon production]
GO:0034587 [piRNA metabolic process]
GO:0035019 [somatic stem cell population maintenance]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045087 [innate immune response]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0050434 [positive regulation of viral transcription]
Show all
 114 aa
13 kDa 		No 0
POLR2H-005
ENSP00000409065
ENST00000455712
C9JLU1 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC3
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 149 aa
17 kDa 		No 0
POLR2H-006
ENSP00000411883
ENST00000430783
P52434 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC3
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0031047 [gene silencing by RNA]
GO:0032481 [positive regulation of type I interferon production]
GO:0034587 [piRNA metabolic process]
GO:0035019 [somatic stem cell population maintenance]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045087 [innate immune response]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0050434 [positive regulation of viral transcription]
Show all
 122 aa
13.8 kDa 		No 0
POLR2H-007
ENSP00000393773
ENST00000443489
P52434 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC3
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0031047 [gene silencing by RNA]
GO:0032481 [positive regulation of type I interferon production]
GO:0034587 [piRNA metabolic process]
GO:0035019 [somatic stem cell population maintenance]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045087 [innate immune response]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0050434 [positive regulation of viral transcription]
Show all
 86 aa
9.7 kDa 		No 0
POLR2H-008
ENSP00000399882
ENST00000452961
P52434 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC3
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0031047 [gene silencing by RNA]
GO:0032481 [positive regulation of type I interferon production]
GO:0034587 [piRNA metabolic process]
GO:0035019 [somatic stem cell population maintenance]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045087 [innate immune response]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0050434 [positive regulation of viral transcription]
Show all
 114 aa
13 kDa 		No 0
POLR2H-009
ENSP00000415536
ENST00000429568
P52434 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC3
Show all
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0031047 [gene silencing by RNA]
GO:0032481 [positive regulation of type I interferon production]
GO:0034587 [piRNA metabolic process]
GO:0035019 [somatic stem cell population maintenance]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045087 [innate immune response]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0050434 [positive regulation of viral transcription]
Show all
 175 aa
19.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.