Cell atlas - ABCE1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ABCE1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS siRNA

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	ABCE1
Gene description	ATP-binding cassette, sub-family E (OABP), member 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)
Single-cell variation	Single-cell variation in protein expression observed.
siRNA	The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA036846
	SHOW MORE

ASSAYS

RNA expression

Human cells

siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA036846	A-431	Cytosol	Intensity
HPA036846	U-2 OS	Cytosol
HPA036846	U-251 MG	Cytosol

siRNA VALIDATION

Antibody

HPA036846

siRNA validation

Validated: Significant downregulation > 25% by both siRNA:s.

Analysis performed in

Cytoplasmic region of segmented cells in 10x-images

siRNA 1

siRNA 2

RFI

72%

63%

p-value

< 0.01


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Sample	Cell line
HPA036846	siRNA 2	U-2 OS
HPA036846	scrambled	U-2 OS
HPA036846	siRNA 1	U-2 OS

GENE INFORMATION
Gene name	ABCE1 (HGNC Symbol)
Synonyms	OABP, RLI, RNASEL1, RNASELI, RNS4I
Description	ATP-binding cassette, sub-family E (OABP), member 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q31.21
Chromosome location (bp)	145097932 - 145129179
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164163 (version 83.38)
Entrez gene	6059
UniProt	P61221 (UniProt - Evidence at protein level)
neXtProt	NX_P61221
Antibodypedia	ABCE1 antibodies

PROTEIN BROWSER

ABCE1-001	ABCE1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCE1-001 ENSP00000296577 ENST00000296577	P61221 [Direct mapping] ATP-binding cassette sub-family E member 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006401 [RNA catabolic process] GO:0008428 [ribonuclease inhibitor activity] GO:0009615 [response to virus] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016887 [ATPase activity] GO:0043086 [negative regulation of catalytic activity] GO:0055085 [transmembrane transport] Show all	599 aa 67.3 kDa	No	0
ABCE1-004 ENSP00000421250 ENST00000502586	D6RGF4 [Direct mapping] ATP-binding cassette sub-family E member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] Show all	210 aa 23.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.