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ABCE1

GENERAL INFORMATION

Gene name

 ABCE1

Gene description

 ATP-binding cassette, sub-family E (OABP), member 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB012476
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable), liver cancer (unfavourable) and colorectal cancer (favourable).
Pancreatic cancer p<0.001
Liver cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB012476

GENE INFORMATION

Gene name

 ABCE1 (HGNC Symbol)

Synonyms

 OABP, RLI, RNASEL1, RNASELI, RNS4I

Description

 ATP-binding cassette, sub-family E (OABP), member 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q31.21

Chromosome location (bp)

 145097932 - 145129179

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164163 (version 83.38)

Entrez gene

 6059

UniProt

 P61221 (UniProt - Evidence at protein level)

neXtProt

 NX_P61221

Antibodypedia

 ABCE1 antibodies

PROTEIN BROWSER
ABCE1-001
ABCE1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABCE1-001
ENSP00000296577
ENST00000296577
P61221 [Direct mapping]
ATP-binding cassette sub-family E member 1
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006401 [RNA catabolic process]
GO:0008428 [ribonuclease inhibitor activity]
GO:0009615 [response to virus]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016887 [ATPase activity]
GO:0043086 [negative regulation of catalytic activity]
GO:0055085 [transmembrane transport]
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 599 aa
67.3 kDa 		No 0
ABCE1-004
ENSP00000421250
ENST00000502586
D6RGF4 [Direct mapping]
ATP-binding cassette sub-family E member 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
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 210 aa
23.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.