Cell atlas - SLC30A8 - The Human Protein Atlas

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SLC30A8

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	SLC30A8
Gene description	Solute carrier family 30 (zinc transporter), member 8
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (U-266/70, U-266/84)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (U-266/70, U-266/84) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	SLC30A8
Synonyms
Description	Solute carrier family 30 (zinc transporter), member 8 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Chromosome	8
Cytoband	q24.11
Chromosome location (bp)	116950273 - 117176714
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164756 (version 83.38)
Entrez gene	169026
UniProt	Q8IWU4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IWU4
Antibodypedia	SLC30A8 antibodies

PROTEIN BROWSER

SLC30A8-001	SLC30A8-002	SLC30A8-003	SLC30A8-005	SLC30A8-006	SLC30A8-007	SLC30A8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC30A8-001 ENSP00000431069 ENST00000519688	Q8IWU4 [Direct mapping] Zinc transporter 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0006829 [zinc II ion transport] GO:0006882 [cellular zinc ion homeostasis] GO:0008270 [zinc ion binding] GO:0008324 [cation transmembrane transporter activity] GO:0009749 [response to glucose] GO:0010043 [response to zinc ion] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0030073 [insulin secretion] GO:0030141 [secretory granule] GO:0030658 [transport vesicle membrane] GO:0030667 [secretory granule membrane] GO:0032024 [positive regulation of insulin secretion] GO:0032119 [sequestering of zinc ion] GO:0042803 [protein homodimerization activity] GO:0044267 [cellular protein metabolic process] GO:0055085 [transmembrane transport] GO:0060627 [regulation of vesicle-mediated transport] GO:0061088 [regulation of sequestering of zinc ion] GO:0071577 [zinc II ion transmembrane transport] Show all	320 aa 35.1 kDa	No	6
SLC30A8-002 ENSP00000415011 ENST00000456015	Q8IWU4 [Direct mapping] Zinc transporter 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0006829 [zinc II ion transport] GO:0006882 [cellular zinc ion homeostasis] GO:0008270 [zinc ion binding] GO:0008324 [cation transmembrane transporter activity] GO:0009749 [response to glucose] GO:0010043 [response to zinc ion] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0030073 [insulin secretion] GO:0030141 [secretory granule] GO:0030658 [transport vesicle membrane] GO:0030667 [secretory granule membrane] GO:0031410 [cytoplasmic vesicle] GO:0032024 [positive regulation of insulin secretion] GO:0032119 [sequestering of zinc ion] GO:0034341 [response to interferon-gamma] GO:0042803 [protein homodimerization activity] GO:0044267 [cellular protein metabolic process] GO:0055085 [transmembrane transport] GO:0060627 [regulation of vesicle-mediated transport] GO:0061088 [regulation of sequestering of zinc ion] GO:0070555 [response to interleukin-1] GO:0071577 [zinc II ion transmembrane transport] Show all	369 aa 40.8 kDa	No	6
SLC30A8-003 ENSP00000428545 ENST00000521243	Q8IWU4 [Direct mapping] Zinc transporter 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0006829 [zinc II ion transport] GO:0006882 [cellular zinc ion homeostasis] GO:0008270 [zinc ion binding] GO:0008324 [cation transmembrane transporter activity] GO:0009749 [response to glucose] GO:0010043 [response to zinc ion] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0030073 [insulin secretion] GO:0030141 [secretory granule] GO:0030658 [transport vesicle membrane] GO:0030667 [secretory granule membrane] GO:0032024 [positive regulation of insulin secretion] GO:0032119 [sequestering of zinc ion] GO:0042803 [protein homodimerization activity] GO:0044267 [cellular protein metabolic process] GO:0055085 [transmembrane transport] GO:0060627 [regulation of vesicle-mediated transport] GO:0061088 [regulation of sequestering of zinc ion] GO:0071577 [zinc II ion transmembrane transport] Show all	320 aa 35.1 kDa	No	6
SLC30A8-005 ENSP00000427760 ENST00000524274	E5RG87 [Direct mapping] Zinc transporter 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0006812 [cation transport] GO:0008324 [cation transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	87 aa 9.5 kDa	No	2
SLC30A8-006 ENSP00000485566 ENST00000518521	A0A096LPF3 [Direct mapping] Zinc transporter 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all		52 aa 5.5 kDa	No	1
SLC30A8-007 ENSP00000485167 ENST00000518396	A0A096LNR0 [Direct mapping] Zinc transporter 8 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all		36 aa 4.1 kDa	No	0
SLC30A8-201 ENSP00000407505 ENST00000427715	Q8IWU4 [Direct mapping] Zinc transporter 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0006829 [zinc II ion transport] GO:0006882 [cellular zinc ion homeostasis] GO:0008270 [zinc ion binding] GO:0008324 [cation transmembrane transporter activity] GO:0009749 [response to glucose] GO:0010043 [response to zinc ion] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0030073 [insulin secretion] GO:0030141 [secretory granule] GO:0030658 [transport vesicle membrane] GO:0030667 [secretory granule membrane] GO:0032024 [positive regulation of insulin secretion] GO:0032119 [sequestering of zinc ion] GO:0042803 [protein homodimerization activity] GO:0044267 [cellular protein metabolic process] GO:0055085 [transmembrane transport] GO:0060627 [regulation of vesicle-mediated transport] GO:0061088 [regulation of sequestering of zinc ion] GO:0071577 [zinc II ion transmembrane transport] Show all	320 aa 35.1 kDa	No	6

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.