Tissue expression of SLC30A8 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLC30A8
Gene description	Solute carrier family 30 (zinc transporter), member 8
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (pancreas)
GTEx:	Group enriched (pancreas, testis)
FANTOM5:	Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (pancreas)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (pancreas, testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pancreas)

GENE INFORMATION
Gene name	SLC30A8
Synonyms
Description	Solute carrier family 30 (zinc transporter), member 8 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Chromosome	8
Cytoband	q24.11
Chromosome location (bp)	116950273 - 117176714
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164756 (version 83.38)
Entrez gene	169026
UniProt	Q8IWU4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IWU4
Antibodypedia	SLC30A8 antibodies

PROTEIN BROWSER

SLC30A8-001	SLC30A8-002	SLC30A8-003	SLC30A8-005	SLC30A8-006	SLC30A8-007	SLC30A8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC30A8-001 ENSP00000431069 ENST00000519688	Q8IWU4 [Direct mapping] Zinc transporter 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0006829 [zinc II ion transport] GO:0006882 [cellular zinc ion homeostasis] GO:0008270 [zinc ion binding] GO:0008324 [cation transmembrane transporter activity] GO:0009749 [response to glucose] GO:0010043 [response to zinc ion] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0030073 [insulin secretion] GO:0030141 [secretory granule] GO:0030658 [transport vesicle membrane] GO:0030667 [secretory granule membrane] GO:0032024 [positive regulation of insulin secretion] GO:0032119 [sequestering of zinc ion] GO:0042803 [protein homodimerization activity] GO:0044267 [cellular protein metabolic process] GO:0055085 [transmembrane transport] GO:0060627 [regulation of vesicle-mediated transport] GO:0061088 [regulation of sequestering of zinc ion] GO:0071577 [zinc II ion transmembrane transport] Show all	320 aa 35.1 kDa	No	6
SLC30A8-002 ENSP00000415011 ENST00000456015	Q8IWU4 [Direct mapping] Zinc transporter 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0006829 [zinc II ion transport] GO:0006882 [cellular zinc ion homeostasis] GO:0008270 [zinc ion binding] GO:0008324 [cation transmembrane transporter activity] GO:0009749 [response to glucose] GO:0010043 [response to zinc ion] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0030073 [insulin secretion] GO:0030141 [secretory granule] GO:0030658 [transport vesicle membrane] GO:0030667 [secretory granule membrane] GO:0031410 [cytoplasmic vesicle] GO:0032024 [positive regulation of insulin secretion] GO:0032119 [sequestering of zinc ion] GO:0034341 [response to interferon-gamma] GO:0042803 [protein homodimerization activity] GO:0044267 [cellular protein metabolic process] GO:0055085 [transmembrane transport] GO:0060627 [regulation of vesicle-mediated transport] GO:0061088 [regulation of sequestering of zinc ion] GO:0070555 [response to interleukin-1] GO:0071577 [zinc II ion transmembrane transport] Show all	369 aa 40.8 kDa	No	6
SLC30A8-003 ENSP00000428545 ENST00000521243	Q8IWU4 [Direct mapping] Zinc transporter 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0006829 [zinc II ion transport] GO:0006882 [cellular zinc ion homeostasis] GO:0008270 [zinc ion binding] GO:0008324 [cation transmembrane transporter activity] GO:0009749 [response to glucose] GO:0010043 [response to zinc ion] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0030073 [insulin secretion] GO:0030141 [secretory granule] GO:0030658 [transport vesicle membrane] GO:0030667 [secretory granule membrane] GO:0032024 [positive regulation of insulin secretion] GO:0032119 [sequestering of zinc ion] GO:0042803 [protein homodimerization activity] GO:0044267 [cellular protein metabolic process] GO:0055085 [transmembrane transport] GO:0060627 [regulation of vesicle-mediated transport] GO:0061088 [regulation of sequestering of zinc ion] GO:0071577 [zinc II ion transmembrane transport] Show all	320 aa 35.1 kDa	No	6
SLC30A8-005 ENSP00000427760 ENST00000524274	E5RG87 [Direct mapping] Zinc transporter 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0006812 [cation transport] GO:0008324 [cation transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	87 aa 9.5 kDa	No	2
SLC30A8-006 ENSP00000485566 ENST00000518521	A0A096LPF3 [Direct mapping] Zinc transporter 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all		52 aa 5.5 kDa	No	1
SLC30A8-007 ENSP00000485167 ENST00000518396	A0A096LNR0 [Direct mapping] Zinc transporter 8 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all		36 aa 4.1 kDa	No	0
SLC30A8-201 ENSP00000407505 ENST00000427715	Q8IWU4 [Direct mapping] Zinc transporter 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0006829 [zinc II ion transport] GO:0006882 [cellular zinc ion homeostasis] GO:0008270 [zinc ion binding] GO:0008324 [cation transmembrane transporter activity] GO:0009749 [response to glucose] GO:0010043 [response to zinc ion] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0030073 [insulin secretion] GO:0030141 [secretory granule] GO:0030658 [transport vesicle membrane] GO:0030667 [secretory granule membrane] GO:0032024 [positive regulation of insulin secretion] GO:0032119 [sequestering of zinc ion] GO:0042803 [protein homodimerization activity] GO:0044267 [cellular protein metabolic process] GO:0055085 [transmembrane transport] GO:0060627 [regulation of vesicle-mediated transport] GO:0061088 [regulation of sequestering of zinc ion] GO:0071577 [zinc II ion transmembrane transport] Show all	320 aa 35.1 kDa	No	6