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SLC30A8

GENERAL INFORMATION

Gene name

 SLC30A8

Gene description

 Solute carrier family 30 (zinc transporter), member 8

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (breast cancer, pancreatic cancer)
HPA (cell line):Group enriched (U-266/70, U-266/84)
HPA (normal tissue):Tissue enhanced (pancreas)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (breast cancer, pancreatic cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 SLC30A8

Synonyms

Description

 Solute carrier family 30 (zinc transporter), member 8 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

Chromosome

 8

Cytoband

 q24.11

Chromosome location (bp)

 116950273 - 117176714

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164756 (version 83.38)

Entrez gene

 169026

UniProt

 Q8IWU4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IWU4

Antibodypedia

 SLC30A8 antibodies

PROTEIN BROWSER
SLC30A8-001
SLC30A8-002
SLC30A8-003
SLC30A8-005
SLC30A8-006
SLC30A8-007
SLC30A8-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC30A8-001
ENSP00000431069
ENST00000519688
Q8IWU4 [Direct mapping]
Zinc transporter 8
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006812 [cation transport]
GO:0006829 [zinc II ion transport]
GO:0006882 [cellular zinc ion homeostasis]
GO:0008270 [zinc ion binding]
GO:0008324 [cation transmembrane transporter activity]
GO:0009749 [response to glucose]
GO:0010043 [response to zinc ion]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030073 [insulin secretion]
GO:0030141 [secretory granule]
GO:0030658 [transport vesicle membrane]
GO:0030667 [secretory granule membrane]
GO:0032024 [positive regulation of insulin secretion]
GO:0032119 [sequestering of zinc ion]
GO:0042803 [protein homodimerization activity]
GO:0044267 [cellular protein metabolic process]
GO:0055085 [transmembrane transport]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0061088 [regulation of sequestering of zinc ion]
GO:0071577 [zinc II ion transmembrane transport]
Show all
 320 aa
35.1 kDa 		No 6
SLC30A8-002
ENSP00000415011
ENST00000456015
Q8IWU4 [Direct mapping]
Zinc transporter 8
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006812 [cation transport]
GO:0006829 [zinc II ion transport]
GO:0006882 [cellular zinc ion homeostasis]
GO:0008270 [zinc ion binding]
GO:0008324 [cation transmembrane transporter activity]
GO:0009749 [response to glucose]
GO:0010043 [response to zinc ion]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030073 [insulin secretion]
GO:0030141 [secretory granule]
GO:0030658 [transport vesicle membrane]
GO:0030667 [secretory granule membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0032024 [positive regulation of insulin secretion]
GO:0032119 [sequestering of zinc ion]
GO:0034341 [response to interferon-gamma]
GO:0042803 [protein homodimerization activity]
GO:0044267 [cellular protein metabolic process]
GO:0055085 [transmembrane transport]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0061088 [regulation of sequestering of zinc ion]
GO:0070555 [response to interleukin-1]
GO:0071577 [zinc II ion transmembrane transport]
Show all
 369 aa
40.8 kDa 		No 6
SLC30A8-003
ENSP00000428545
ENST00000521243
Q8IWU4 [Direct mapping]
Zinc transporter 8
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006812 [cation transport]
GO:0006829 [zinc II ion transport]
GO:0006882 [cellular zinc ion homeostasis]
GO:0008270 [zinc ion binding]
GO:0008324 [cation transmembrane transporter activity]
GO:0009749 [response to glucose]
GO:0010043 [response to zinc ion]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030073 [insulin secretion]
GO:0030141 [secretory granule]
GO:0030658 [transport vesicle membrane]
GO:0030667 [secretory granule membrane]
GO:0032024 [positive regulation of insulin secretion]
GO:0032119 [sequestering of zinc ion]
GO:0042803 [protein homodimerization activity]
GO:0044267 [cellular protein metabolic process]
GO:0055085 [transmembrane transport]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0061088 [regulation of sequestering of zinc ion]
GO:0071577 [zinc II ion transmembrane transport]
Show all
 320 aa
35.1 kDa 		No 6
SLC30A8-005
ENSP00000427760
ENST00000524274
E5RG87 [Direct mapping]
Zinc transporter 8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0006812 [cation transport]
GO:0008324 [cation transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
 87 aa
9.5 kDa 		No 2
SLC30A8-006
ENSP00000485566
ENST00000518521
A0A096LPF3 [Direct mapping]
Zinc transporter 8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
 52 aa
5.5 kDa 		No 1
SLC30A8-007
ENSP00000485167
ENST00000518396
A0A096LNR0 [Direct mapping]
Zinc transporter 8
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
 36 aa
4.1 kDa 		No 0
SLC30A8-201
ENSP00000407505
ENST00000427715
Q8IWU4 [Direct mapping]
Zinc transporter 8
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006812 [cation transport]
GO:0006829 [zinc II ion transport]
GO:0006882 [cellular zinc ion homeostasis]
GO:0008270 [zinc ion binding]
GO:0008324 [cation transmembrane transporter activity]
GO:0009749 [response to glucose]
GO:0010043 [response to zinc ion]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030073 [insulin secretion]
GO:0030141 [secretory granule]
GO:0030658 [transport vesicle membrane]
GO:0030667 [secretory granule membrane]
GO:0032024 [positive regulation of insulin secretion]
GO:0032119 [sequestering of zinc ion]
GO:0042803 [protein homodimerization activity]
GO:0044267 [cellular protein metabolic process]
GO:0055085 [transmembrane transport]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0061088 [regulation of sequestering of zinc ion]
GO:0071577 [zinc II ion transmembrane transport]
Show all
 320 aa
35.1 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.