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SYK

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GENERAL INFORMATION

Gene name

 SYK

Gene description

 Spleen tyrosine kinase

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the plasma membrane & cytosol. In addition localized to vesicles.

RNA cell category

 Cell line enhanced (Daudi, HL-60, REH, HEL)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (approved), Cytosol (approved)

Additional location

 In addition localized to the Vesicles (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA001384
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Daudi, HL-60, REH, HEL)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the plasma membrane & cytosol. In addition localized to vesicles.

Main location

 Plasma membrane (approved), Cytosol (approved)

Additional location

 Vesicles (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA001384 A-431 Nucleoplasm
Plasma membrane
Cytosol
HPA001384 HEK 293 Plasma membrane
Cytosol Intensity
HPA001384 U-2 OS Vesicles
Cytosol Spatial

GENE INFORMATION

Gene name

 SYK

Synonyms

Description

 Spleen tyrosine kinase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Chromosome

 9

Cytoband

 q22.2

Chromosome location (bp)

 90801787 - 90898549

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165025 (version 83.38)

Entrez gene

 6850

UniProt

 P43405 (UniProt - Evidence at protein level)

neXtProt

 NX_P43405

Antibodypedia

 SYK antibodies

PROTEIN BROWSER
SYK-001
SYK-002
SYK-003
SYK-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SYK-001
ENSP00000364907
ENST00000375754
P43405 [Direct mapping]
Tyrosine-protein kinase SYK
A0A024R244 [Target identity:100%; Query identity:100%]
Tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001525 [angiogenesis]
GO:0001820 [serotonin secretion]
GO:0001945 [lymph vessel development]
GO:0002092 [positive regulation of receptor internalization]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002281 [macrophage activation involved in immune response]
GO:0002283 [neutrophil activation involved in immune response]
GO:0002366 [leukocyte activation involved in immune response]
GO:0002554 [serotonin secretion by platelet]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007167 [enzyme linked receptor protein signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007257 [activation of JUN kinase activity]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0009887 [organ morphogenesis]
GO:0010543 [regulation of platelet activation]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016032 [viral process]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019370 [leukotriene biosynthetic process]
GO:0019815 [B cell receptor complex]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030593 [neutrophil chemotaxis]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032009 [early phagosome]
GO:0032481 [positive regulation of type I interferon production]
GO:0032928 [regulation of superoxide anion generation]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042101 [T cell receptor complex]
GO:0042742 [defense response to bacterium]
GO:0042991 [transcription factor import into nucleus]
GO:0043234 [protein complex]
GO:0043306 [positive regulation of mast cell degranulation]
GO:0043313 [regulation of neutrophil degranulation]
GO:0043366 [beta selection]
GO:0045087 [innate immune response]
GO:0045401 [positive regulation of interleukin-3 biosynthetic process]
GO:0045425 [positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process]
GO:0045579 [positive regulation of B cell differentiation]
GO:0045588 [positive regulation of gamma-delta T cell differentiation]
GO:0045780 [positive regulation of bone resorption]
GO:0046638 [positive regulation of alpha-beta T cell differentiation]
GO:0046641 [positive regulation of alpha-beta T cell proliferation]
GO:0046777 [protein autophosphorylation]
GO:0048514 [blood vessel morphogenesis]
GO:0050715 [positive regulation of cytokine secretion]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050764 [regulation of phagocytosis]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0050853 [B cell receptor signaling pathway]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0071226 [cellular response to molecule of fungal origin]
GO:0090237 [regulation of arachidonic acid secretion]
GO:0090330 [regulation of platelet aggregation]
Show all
 635 aa
72.1 kDa 		No 0
SYK-002
ENSP00000364898
ENST00000375746
P43405 [Direct mapping]
Tyrosine-protein kinase SYK
A0A024R244 [Target identity:100%; Query identity:100%]
Tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001945 [lymph vessel development]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002281 [macrophage activation involved in immune response]
GO:0002283 [neutrophil activation involved in immune response]
GO:0002366 [leukocyte activation involved in immune response]
GO:0002554 [serotonin secretion by platelet]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0009887 [organ morphogenesis]
GO:0010543 [regulation of platelet activation]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016032 [viral process]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030593 [neutrophil chemotaxis]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032009 [early phagosome]
GO:0032928 [regulation of superoxide anion generation]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042101 [T cell receptor complex]
GO:0042742 [defense response to bacterium]
GO:0042991 [transcription factor import into nucleus]
GO:0043234 [protein complex]
GO:0043306 [positive regulation of mast cell degranulation]
GO:0043313 [regulation of neutrophil degranulation]
GO:0045087 [innate immune response]
GO:0045579 [positive regulation of B cell differentiation]
GO:0045780 [positive regulation of bone resorption]
GO:0046641 [positive regulation of alpha-beta T cell proliferation]
GO:0048514 [blood vessel morphogenesis]
GO:0050764 [regulation of phagocytosis]
GO:0050853 [B cell receptor signaling pathway]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0071226 [cellular response to molecule of fungal origin]
GO:0090237 [regulation of arachidonic acid secretion]
GO:0090330 [regulation of platelet aggregation]
Show all
 635 aa
72.1 kDa 		No 0
SYK-003
ENSP00000364899
ENST00000375747
P43405 [Direct mapping]
Tyrosine-protein kinase SYK
A0A024R273 [Target identity:100%; Query identity:100%]
Tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001945 [lymph vessel development]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002281 [macrophage activation involved in immune response]
GO:0002283 [neutrophil activation involved in immune response]
GO:0002366 [leukocyte activation involved in immune response]
GO:0002554 [serotonin secretion by platelet]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0009887 [organ morphogenesis]
GO:0010543 [regulation of platelet activation]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016032 [viral process]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030593 [neutrophil chemotaxis]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032009 [early phagosome]
GO:0032928 [regulation of superoxide anion generation]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042101 [T cell receptor complex]
GO:0042742 [defense response to bacterium]
GO:0042991 [transcription factor import into nucleus]
GO:0043234 [protein complex]
GO:0043306 [positive regulation of mast cell degranulation]
GO:0043313 [regulation of neutrophil degranulation]
GO:0045087 [innate immune response]
GO:0045579 [positive regulation of B cell differentiation]
GO:0045780 [positive regulation of bone resorption]
GO:0046641 [positive regulation of alpha-beta T cell proliferation]
GO:0048514 [blood vessel morphogenesis]
GO:0050764 [regulation of phagocytosis]
GO:0050853 [B cell receptor signaling pathway]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0071226 [cellular response to molecule of fungal origin]
GO:0090237 [regulation of arachidonic acid secretion]
GO:0090330 [regulation of platelet aggregation]
Show all
 612 aa
69.5 kDa 		No 0
SYK-004
ENSP00000364904
ENST00000375751
P43405 [Direct mapping]
Tyrosine-protein kinase SYK
A0A024R273 [Target identity:100%; Query identity:100%]
Tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001945 [lymph vessel development]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002281 [macrophage activation involved in immune response]
GO:0002283 [neutrophil activation involved in immune response]
GO:0002366 [leukocyte activation involved in immune response]
GO:0002554 [serotonin secretion by platelet]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0009887 [organ morphogenesis]
GO:0010543 [regulation of platelet activation]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016032 [viral process]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030593 [neutrophil chemotaxis]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032009 [early phagosome]
GO:0032928 [regulation of superoxide anion generation]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042101 [T cell receptor complex]
GO:0042742 [defense response to bacterium]
GO:0042991 [transcription factor import into nucleus]
GO:0043234 [protein complex]
GO:0043306 [positive regulation of mast cell degranulation]
GO:0043313 [regulation of neutrophil degranulation]
GO:0045087 [innate immune response]
GO:0045579 [positive regulation of B cell differentiation]
GO:0045780 [positive regulation of bone resorption]
GO:0046641 [positive regulation of alpha-beta T cell proliferation]
GO:0048514 [blood vessel morphogenesis]
GO:0050764 [regulation of phagocytosis]
GO:0050853 [B cell receptor signaling pathway]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0071226 [cellular response to molecule of fungal origin]
GO:0090237 [regulation of arachidonic acid secretion]
GO:0090330 [regulation of platelet aggregation]
Show all
 612 aa
69.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.