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Moderate to strong cytoplasmic positivity was observed in malignant lymphomas, colorectal, ovarian, endometrial and gastric cancers. Other malignancies were in general weakly stained or negative.
GENE INFORMATION
Gene name
SYK
Synonyms
Description
Spleen tyrosine kinase (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity] GO:0001525 [angiogenesis] GO:0001820 [serotonin secretion] GO:0001945 [lymph vessel development] GO:0002092 [positive regulation of receptor internalization] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0002281 [macrophage activation involved in immune response] GO:0002283 [neutrophil activation involved in immune response] GO:0002366 [leukocyte activation involved in immune response] GO:0002554 [serotonin secretion by platelet] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004716 [receptor signaling protein tyrosine kinase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0007159 [leukocyte cell-cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007167 [enzyme linked receptor protein signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007257 [activation of JUN kinase activity] GO:0007596 [blood coagulation] GO:0008283 [cell proliferation] GO:0009887 [organ morphogenesis] GO:0010543 [regulation of platelet activation] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016032 [viral process] GO:0018105 [peptidyl-serine phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019370 [leukotriene biosynthetic process] GO:0019815 [B cell receptor complex] GO:0019901 [protein kinase binding] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030593 [neutrophil chemotaxis] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0032009 [early phagosome] GO:0032481 [positive regulation of type I interferon production] GO:0032928 [regulation of superoxide anion generation] GO:0033630 [positive regulation of cell adhesion mediated by integrin] GO:0035556 [intracellular signal transduction] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042101 [T cell receptor complex] GO:0042742 [defense response to bacterium] GO:0042991 [transcription factor import into nucleus] GO:0043234 [protein complex] GO:0043306 [positive regulation of mast cell degranulation] GO:0043313 [regulation of neutrophil degranulation] GO:0043366 [beta selection] GO:0045087 [innate immune response] GO:0045401 [positive regulation of interleukin-3 biosynthetic process] GO:0045425 [positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process] GO:0045579 [positive regulation of B cell differentiation] GO:0045588 [positive regulation of gamma-delta T cell differentiation] GO:0045780 [positive regulation of bone resorption] GO:0046638 [positive regulation of alpha-beta T cell differentiation] GO:0046641 [positive regulation of alpha-beta T cell proliferation] GO:0046777 [protein autophosphorylation] GO:0048514 [blood vessel morphogenesis] GO:0050715 [positive regulation of cytokine secretion] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050764 [regulation of phagocytosis] GO:0050850 [positive regulation of calcium-mediated signaling] GO:0050853 [B cell receptor signaling pathway] GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0071226 [cellular response to molecule of fungal origin] GO:0090237 [regulation of arachidonic acid secretion] GO:0090330 [regulation of platelet aggregation]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis] GO:0001945 [lymph vessel development] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0002281 [macrophage activation involved in immune response] GO:0002283 [neutrophil activation involved in immune response] GO:0002366 [leukocyte activation involved in immune response] GO:0002554 [serotonin secretion by platelet] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0007159 [leukocyte cell-cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007596 [blood coagulation] GO:0008283 [cell proliferation] GO:0009887 [organ morphogenesis] GO:0010543 [regulation of platelet activation] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016032 [viral process] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030593 [neutrophil chemotaxis] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0032009 [early phagosome] GO:0032928 [regulation of superoxide anion generation] GO:0033630 [positive regulation of cell adhesion mediated by integrin] GO:0035556 [intracellular signal transduction] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042101 [T cell receptor complex] GO:0042742 [defense response to bacterium] GO:0042991 [transcription factor import into nucleus] GO:0043234 [protein complex] GO:0043306 [positive regulation of mast cell degranulation] GO:0043313 [regulation of neutrophil degranulation] GO:0045087 [innate immune response] GO:0045579 [positive regulation of B cell differentiation] GO:0045780 [positive regulation of bone resorption] GO:0046641 [positive regulation of alpha-beta T cell proliferation] GO:0048514 [blood vessel morphogenesis] GO:0050764 [regulation of phagocytosis] GO:0050853 [B cell receptor signaling pathway] GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0071226 [cellular response to molecule of fungal origin] GO:0090237 [regulation of arachidonic acid secretion] GO:0090330 [regulation of platelet aggregation]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis] GO:0001945 [lymph vessel development] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0002281 [macrophage activation involved in immune response] GO:0002283 [neutrophil activation involved in immune response] GO:0002366 [leukocyte activation involved in immune response] GO:0002554 [serotonin secretion by platelet] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0007159 [leukocyte cell-cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007596 [blood coagulation] GO:0008283 [cell proliferation] GO:0009887 [organ morphogenesis] GO:0010543 [regulation of platelet activation] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016032 [viral process] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030593 [neutrophil chemotaxis] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0032009 [early phagosome] GO:0032928 [regulation of superoxide anion generation] GO:0033630 [positive regulation of cell adhesion mediated by integrin] GO:0035556 [intracellular signal transduction] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042101 [T cell receptor complex] GO:0042742 [defense response to bacterium] GO:0042991 [transcription factor import into nucleus] GO:0043234 [protein complex] GO:0043306 [positive regulation of mast cell degranulation] GO:0043313 [regulation of neutrophil degranulation] GO:0045087 [innate immune response] GO:0045579 [positive regulation of B cell differentiation] GO:0045780 [positive regulation of bone resorption] GO:0046641 [positive regulation of alpha-beta T cell proliferation] GO:0048514 [blood vessel morphogenesis] GO:0050764 [regulation of phagocytosis] GO:0050853 [B cell receptor signaling pathway] GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0071226 [cellular response to molecule of fungal origin] GO:0090237 [regulation of arachidonic acid secretion] GO:0090330 [regulation of platelet aggregation]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis] GO:0001945 [lymph vessel development] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0002281 [macrophage activation involved in immune response] GO:0002283 [neutrophil activation involved in immune response] GO:0002366 [leukocyte activation involved in immune response] GO:0002554 [serotonin secretion by platelet] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0007159 [leukocyte cell-cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007596 [blood coagulation] GO:0008283 [cell proliferation] GO:0009887 [organ morphogenesis] GO:0010543 [regulation of platelet activation] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016032 [viral process] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030593 [neutrophil chemotaxis] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0032009 [early phagosome] GO:0032928 [regulation of superoxide anion generation] GO:0033630 [positive regulation of cell adhesion mediated by integrin] GO:0035556 [intracellular signal transduction] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042101 [T cell receptor complex] GO:0042742 [defense response to bacterium] GO:0042991 [transcription factor import into nucleus] GO:0043234 [protein complex] GO:0043306 [positive regulation of mast cell degranulation] GO:0043313 [regulation of neutrophil degranulation] GO:0045087 [innate immune response] GO:0045579 [positive regulation of B cell differentiation] GO:0045780 [positive regulation of bone resorption] GO:0046641 [positive regulation of alpha-beta T cell proliferation] GO:0048514 [blood vessel morphogenesis] GO:0050764 [regulation of phagocytosis] GO:0050853 [B cell receptor signaling pathway] GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0071226 [cellular response to molecule of fungal origin] GO:0090237 [regulation of arachidonic acid secretion] GO:0090330 [regulation of platelet aggregation]