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Gene name

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Chromosome

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In atlas

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Reliability

Reliability

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Method

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Searches

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Cancer

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Detectable

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Detectable

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ABCA1
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ABCA1

Gene description

ATP-binding cassette, sub-family A (ABC1), member 1

Protein class

Disease related genes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General membranous and cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB069889
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
N/A
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

ABCA1 (HGNC Symbol)

Synonyms

ABC1, HDLDT1, TGD

Description

ATP-binding cassette, sub-family A (ABC1), member 1 (HGNC Symbol)

Entrez gene summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q31.1

Chromosome location (bp)

104781002 - 104928237

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000165029 (version 83.38)

Entrez gene

19

UniProt

O95477 (UniProt - Evidence at protein level)

neXtProt

NX_O95477

Antibodypedia

ABCA1 antibodies

PROTEIN BROWSER

ABCA1-001
ABCA1-002
ABCA1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCA1-001
ENSP00000416623
ENST00000423487
B1AMI2 [Direct mapping]
ATP-binding cassette sub-family A member 1; ATP-binding cassette, sub-family A (ABC1), member 1, isoform CRA_b
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005887 [integral component of plasma membrane]
GO:0006911 [phagocytosis, engulfment]
GO:0033344 [cholesterol efflux]
GO:0034186 [apolipoprotein A-I binding]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0043691 [reverse cholesterol transport]
GO:0055085 [transmembrane transport]
Show all
363 aa
41.1 kDa
No 2
ABCA1-002
ENSP00000363868
ENST00000374736
O95477 [Direct mapping]
ATP-binding cassette sub-family A member 1
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002790 [peptide secretion]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005543 [phospholipid binding]
GO:0005548 [phospholipid transporter activity]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006497 [protein lipidation]
GO:0006911 [phagocytosis, engulfment]
GO:0007040 [lysosome organization]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007584 [response to nutrient]
GO:0008203 [cholesterol metabolic process]
GO:0008509 [anion transmembrane transporter activity]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0016197 [endosomal transport]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0019905 [syntaxin binding]
GO:0030139 [endocytic vesicle]
GO:0030301 [cholesterol transport]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031267 [small GTPase binding]
GO:0032367 [intracellular cholesterol transport]
GO:0032489 [regulation of Cdc42 protein signal transduction]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034185 [apolipoprotein binding]
GO:0034186 [apolipoprotein A-I binding]
GO:0034188 [apolipoprotein A-I receptor activity]
GO:0034364 [high-density lipoprotein particle]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034616 [response to laminar fluid shear stress]
GO:0038027 [apolipoprotein A-I-mediated signaling pathway]
GO:0042157 [lipoprotein metabolic process]
GO:0042158 [lipoprotein biosynthetic process]
GO:0042493 [response to drug]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0042632 [cholesterol homeostasis]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043691 [reverse cholesterol transport]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045121 [membrane raft]
GO:0045332 [phospholipid translocation]
GO:0045335 [phagocytic vesicle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050702 [interleukin-1 beta secretion]
GO:0051117 [ATPase binding]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:0055098 [response to low-density lipoprotein particle]
GO:0060155 [platelet dense granule organization]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071300 [cellular response to retinoic acid]
GO:0071397 [cellular response to cholesterol]
GO:0098656 [anion transmembrane transport]
Show all
2261 aa
254.3 kDa
No >9
ABCA1-004
ENSP00000363865
ENST00000374733
B1AMI1 [Direct mapping]
ATP-binding cassette sub-family A member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
123 aa
13.8 kDa
No 0

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