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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CDX2
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    TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CDX2

Gene description

Caudal type homeobox 2

Protein class

Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (colorectal cancer)
HPA (cell line):Group enriched (CACO-2, CAPAN-2, HEK93)
HPA (normal tissue):Group enriched (colon, duodenum, rectum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in intestinal tract

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
CAB002221
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (colorectal cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB002221

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Colorectal cancer and a few cases of gastric cancer showed moderate to strong nuclear immunoreactivity. Other malignancies were negative.

GENE INFORMATION

Gene name

CDX2 (HGNC Symbol)

Synonyms

CDX3

Description

Caudal type homeobox 2 (HGNC Symbol)

Entrez gene summary

This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]

Chromosome

13

Cytoband

q12.2

Chromosome location (bp)

27962137 - 27971139

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000165556 (version 83.38)

Entrez gene

1045

UniProt

Q99626 (UniProt - Evidence at transcript level)

neXtProt

NX_Q99626

Antibodypedia

CDX2 antibodies

PROTEIN BROWSER

CDX2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDX2-001
ENSP00000370408
ENST00000381020
Q99626 [Direct mapping]
Homeobox protein CDX-2
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000794 [condensed nuclear chromosome]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001568 [blood vessel development]
GO:0001824 [blastocyst development]
GO:0001829 [trophectodermal cell differentiation]
GO:0001890 [placenta development]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0007389 [pattern specification process]
GO:0008284 [positive regulation of cell proliferation]
GO:0008333 [endosome to lysosome transport]
GO:0009887 [organ morphogenesis]
GO:0009948 [anterior/posterior axis specification]
GO:0009952 [anterior/posterior pattern specification]
GO:0014807 [regulation of somitogenesis]
GO:0017053 [transcriptional repressor complex]
GO:0030154 [cell differentiation]
GO:0035019 [somatic stem cell population maintenance]
GO:0043234 [protein complex]
GO:0043565 [sequence-specific DNA binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045597 [positive regulation of cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0060575 [intestinal epithelial cell differentiation]
GO:0060711 [labyrinthine layer development]
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313 aa
33.5 kDa
No 0

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