Colorectal cancer and a few cases of gastric cancer showed moderate to strong nuclear immunoreactivity. Other malignancies were negative.
CDX2 (HGNC Symbol)
Caudal type homeobox 2 (HGNC Symbol)
Entrez gene summary
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]