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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CDX2
  • premium

    TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CDX2

Gene description

Caudal type homeobox 2

Protein class

Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (colon, duodenum, rectum, small intestine)
GTEx:Group enriched (colon, small intestine)
FANTOM5:Tissue enhanced (appendix, colon)

Protein evidence

Evidence at protein level

Protein expression

Nuclear expression in intestinal tract

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
CAB002221
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, duodenum, rectum, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, colon)

GENE INFORMATION

Gene name

CDX2 (HGNC Symbol)

Synonyms

CDX3

Description

Caudal type homeobox 2 (HGNC Symbol)

Entrez gene summary

This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]

Chromosome

13

Cytoband

q12.2

Chromosome location (bp)

27962137 - 27971139

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000165556 (version 83.38)

Entrez gene

1045

UniProt

Q99626 (UniProt - Evidence at transcript level)

neXtProt

NX_Q99626

Antibodypedia

CDX2 antibodies

PROTEIN BROWSER

CDX2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDX2-001
ENSP00000370408
ENST00000381020
Q99626 [Direct mapping]
Homeobox protein CDX-2
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000794 [condensed nuclear chromosome]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001568 [blood vessel development]
GO:0001824 [blastocyst development]
GO:0001829 [trophectodermal cell differentiation]
GO:0001890 [placenta development]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0007389 [pattern specification process]
GO:0008284 [positive regulation of cell proliferation]
GO:0008333 [endosome to lysosome transport]
GO:0009887 [organ morphogenesis]
GO:0009948 [anterior/posterior axis specification]
GO:0009952 [anterior/posterior pattern specification]
GO:0014807 [regulation of somitogenesis]
GO:0017053 [transcriptional repressor complex]
GO:0030154 [cell differentiation]
GO:0035019 [somatic stem cell population maintenance]
GO:0043234 [protein complex]
GO:0043565 [sequence-specific DNA binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045597 [positive regulation of cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0060575 [intestinal epithelial cell differentiation]
GO:0060711 [labyrinthine layer development]
Show all
313 aa
33.5 kDa
No 0

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