Expression of TTC7B in cancer - Summary

GENERAL INFORMATION
Gene name	TTC7B
Gene description	Tetratricopeptide repeat domain 7B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct expression in brain. Membranous expression in most tissues, highly abundant in placenta, stomach and renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA058363 , HPA059577
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA058363	HPA059577

GENE INFORMATION
Gene name	TTC7B (HGNC Symbol)
Synonyms	TTC7L1
Description	Tetratricopeptide repeat domain 7B (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q32.11
Chromosome location (bp)	90524564 - 90816479
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165914 (version 83.38)
Entrez gene	145567
UniProt	Q86TV6 (UniProt - Evidence at protein level)
neXtProt	NX_Q86TV6
Antibodypedia	TTC7B antibodies

PROTEIN BROWSER

TTC7B-001	TTC7B-004	TTC7B-005	TTC7B-009	TTC7B-012	TTC7B-013	TTC7B-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TTC7B-001 ENSP00000336127 ENST00000328459	Q86TV6 [Direct mapping] Tetratricopeptide repeat protein 7B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	843 aa 94.2 kDa	No	0
TTC7B-004 ENSP00000451201 ENST00000553948	G3V3E4 [Direct mapping] Tetratricopeptide repeat protein 7B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		48 aa 5.4 kDa	No	0
TTC7B-005 ENSP00000451238 ENST00000557766	G3V3H1 [Direct mapping] Tetratricopeptide repeat protein 7B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		205 aa 23.5 kDa	No	0
TTC7B-009 ENSP00000451928 ENST00000554462	H0YJP9 [Direct mapping] Tetratricopeptide repeat protein 7B Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	175 aa 19.5 kDa	No	0
TTC7B-012 ENSP00000452594 ENST00000555894	H0YK02 [Direct mapping] Tetratricopeptide repeat protein 7B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		213 aa 22.3 kDa	No	0
TTC7B-013 ENSP00000452031 ENST00000557292	H0YJS2 [Direct mapping] Tetratricopeptide repeat protein 7B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	271 aa 29.3 kDa	No	0
TTC7B-015 ENSP00000451440 ENST00000553972	A0A0C4DGK5 [Direct mapping] Tetratricopeptide repeat protein 7B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	330 aa 36.2 kDa	No	0