Expression of NELL1 in cancer - Summary - The Human Protein Atlas

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NELL1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NELL1
Gene description	Neural EGFL like 1
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (melanoma)
HPA (cell line):	Cell line enhanced (SH-SY5Y, U-2 OS, WM-115)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, kidney)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in CNS, kidney, testis and prostate.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA051535
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051535

GENE INFORMATION
Gene name	NELL1 (HGNC Symbol)
Synonyms	FLJ45906, IDH3GL
Description	Neural EGFL like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Chromosome	11
Cytoband	p15.1
Chromosome location (bp)	20669551 - 21575681
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165973 (version 83.38)
Entrez gene	4745
UniProt	Q92832 (UniProt - Evidence at protein level)
neXtProt	NX_Q92832
Antibodypedia	NELL1 antibodies

PROTEIN BROWSER

NELL1-001	NELL1-002	NELL1-003	NELL1-201	NELL1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NELL1-001 ENSP00000349654 ENST00000357134	Q92832 [Direct mapping] Protein kinase C-binding protein NELL1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0007399 [nervous system development] GO:0010468 [regulation of gene expression] GO:0030154 [cell differentiation] GO:0030501 [positive regulation of bone mineralization] GO:0033689 [negative regulation of osteoblast proliferation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0048471 [perinuclear region of cytoplasm] GO:2000599 [negative regulation of cyclin catabolic process] Show all	810 aa 89.6 kDa	Yes	0
NELL1-002 ENSP00000298925 ENST00000298925	J3KNC5 [Direct mapping] NEL-like 1 (Chicken), isoform CRA_a; Protein kinase C-binding protein NELL1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	838 aa 92.8 kDa	Yes	0
NELL1-003 ENSP00000437170 ENST00000532434	Q92832 [Direct mapping] Protein kinase C-binding protein NELL1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0007399 [nervous system development] GO:0010468 [regulation of gene expression] GO:0030154 [cell differentiation] GO:0030501 [positive regulation of bone mineralization] GO:0033689 [negative regulation of osteoblast proliferation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0048471 [perinuclear region of cytoplasm] GO:2000599 [negative regulation of cyclin catabolic process] Show all	763 aa 84.4 kDa	Yes	0
NELL1-201 ENSP00000317837 ENST00000325319	F5H6I3 [Direct mapping] Protein kinase C-binding protein NELL1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	753 aa 83 kDa	Yes	0
NELL1-202 ENSP00000479479 ENST00000619031	K9UUD5 [Direct mapping] NELL-1 protein short isoform; Protein kinase C-binding protein NELL1 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	570 aa 62.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.