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NELL1

GENERAL INFORMATION

Gene name

 NELL1

Gene description

 Neural EGFL like 1

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, kidney)
GTEx:Tissue enhanced (cerebral cortex)
FANTOM5:Tissue enhanced (brain, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression with a granular pattern in CNS, kidney, testis and prostate.

DATA RELIABILITY

Data reliability
description

 Pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA051535
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, hippocampus)

GENE INFORMATION

Gene name

 NELL1 (HGNC Symbol)

Synonyms

 FLJ45906, IDH3GL

Description

 Neural EGFL like 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Chromosome

 11

Cytoband

 p15.1

Chromosome location (bp)

 20669551 - 21575681

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165973 (version 83.38)

Entrez gene

 4745

UniProt

 Q92832 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92832

Antibodypedia

 NELL1 antibodies

PROTEIN BROWSER
NELL1-001
NELL1-002
NELL1-003
NELL1-201
NELL1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NELL1-001
ENSP00000349654
ENST00000357134
Q92832 [Direct mapping]
Protein kinase C-binding protein NELL1
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0007399 [nervous system development]
GO:0010468 [regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030501 [positive regulation of bone mineralization]
GO:0033689 [negative regulation of osteoblast proliferation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:2000599 [negative regulation of cyclin catabolic process]
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 810 aa
89.6 kDa 		Yes 0
NELL1-002
ENSP00000298925
ENST00000298925
J3KNC5 [Direct mapping]
NEL-like 1 (Chicken), isoform CRA_a; Protein kinase C-binding protein NELL1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
 838 aa
92.8 kDa 		Yes 0
NELL1-003
ENSP00000437170
ENST00000532434
Q92832 [Direct mapping]
Protein kinase C-binding protein NELL1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0007399 [nervous system development]
GO:0010468 [regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030501 [positive regulation of bone mineralization]
GO:0033689 [negative regulation of osteoblast proliferation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:2000599 [negative regulation of cyclin catabolic process]
Show all
 763 aa
84.4 kDa 		Yes 0
NELL1-201
ENSP00000317837
ENST00000325319
F5H6I3 [Direct mapping]
Protein kinase C-binding protein NELL1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
 753 aa
83 kDa 		Yes 0
NELL1-202
ENSP00000479479
ENST00000619031
K9UUD5 [Direct mapping]
NELL-1 protein short isoform; Protein kinase C-binding protein NELL1
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Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
 570 aa
62.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.