Cell atlas - WEE1 - The Human Protein Atlas

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WEE1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli

Human cell
	Nucleoli

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GENERAL INFORMATION
Gene name	WEE1
Gene description	WEE1 G2 checkpoint kinase
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA068845
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli.

Main location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA068845	RH-30	Nucleoli
	HPA068845	RT4	Nucleoli	Intensity
	HPA068845	U-2 OS	Nucleoli

GENE INFORMATION
Gene name	WEE1 (HGNC Symbol)
Synonyms	WEE1A
Description	WEE1 G2 checkpoint kinase (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	9573681 - 9593457
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166483 (version 83.38)
Entrez gene	7465
UniProt	P30291 (UniProt - Evidence at protein level)
neXtProt	NX_P30291
Antibodypedia	WEE1 antibodies

PROTEIN BROWSER

WEE1-001	WEE1-002	WEE1-004	WEE1-005	WEE1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WEE1-001 ENSP00000402084 ENST00000450114	P30291 [Direct mapping] Wee1-like protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000226 [microtubule cytoskeleton organization] GO:0000278 [mitotic cell cycle] GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007067 [mitotic nuclear division] GO:0007596 [blood coagulation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030010 [establishment of cell polarity] GO:0048812 [neuron projection morphogenesis] GO:0051301 [cell division] GO:0051726 [regulation of cell cycle] Show all	646 aa 71.6 kDa	No	0
WEE1-002 ENSP00000299613 ENST00000299613	P30291 [Direct mapping] Wee1-like protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006468 [protein phosphorylation] GO:0007067 [mitotic nuclear division] GO:0007596 [blood coagulation] GO:0051301 [cell division] GO:0051726 [regulation of cell cycle] Show all	432 aa 49.1 kDa	No	0
WEE1-004 ENSP00000434446 ENST00000524612	E9PQ51 [Direct mapping] Wee1-like protein kinase Show all	SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	162 aa 18.1 kDa	No	0
WEE1-005 ENSP00000434148 ENST00000530712	E9PRU3 [Direct mapping] Wee1-like protein kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	214 aa 24 kDa	No	0
WEE1-008 ENSP00000432284 ENST00000527848	E9PRI3 [Direct mapping] Wee1-like protein kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		99 aa 11.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.