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WEE1

GENERAL INFORMATION

Gene name

 WEE1

Gene description

 WEE1 G2 checkpoint kinase

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB004619
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
CAB004619

GENE INFORMATION

Gene name

 WEE1 (HGNC Symbol)

Synonyms

 WEE1A

Description

 WEE1 G2 checkpoint kinase (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p15.4

Chromosome location (bp)

 9573681 - 9593457

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166483 (version 83.38)

Entrez gene

 7465

UniProt

 P30291 (UniProt - Evidence at protein level)

neXtProt

 NX_P30291

Antibodypedia

 WEE1 antibodies

PROTEIN BROWSER
WEE1-001
WEE1-002
WEE1-004
WEE1-005
WEE1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WEE1-001
ENSP00000402084
ENST00000450114
P30291 [Direct mapping]
Wee1-like protein kinase
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0007596 [blood coagulation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030010 [establishment of cell polarity]
GO:0048812 [neuron projection morphogenesis]
GO:0051301 [cell division]
GO:0051726 [regulation of cell cycle]
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 646 aa
71.6 kDa 		No 0
WEE1-002
ENSP00000299613
ENST00000299613
P30291 [Direct mapping]
Wee1-like protein kinase
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0007596 [blood coagulation]
GO:0051301 [cell division]
GO:0051726 [regulation of cell cycle]
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 432 aa
49.1 kDa 		No 0
WEE1-004
ENSP00000434446
ENST00000524612
E9PQ51 [Direct mapping]
Wee1-like protein kinase
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   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 162 aa
18.1 kDa 		No 0
WEE1-005
ENSP00000434148
ENST00000530712
E9PRU3 [Direct mapping]
Wee1-like protein kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 214 aa
24 kDa 		No 0
WEE1-008
ENSP00000432284
ENST00000527848
E9PRI3 [Direct mapping]
Wee1-like protein kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 99 aa
11.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.