We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
AXL
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

AXL

Gene description

AXL receptor tyrosine kinase

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues including testis and renal tubules.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Uncertain based on 3 antibodies.
HPA037422 , HPA037423 , CAB032501
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA037422
HPA037423
CAB032501

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues were generally negative. A few cases of endometrial, ovarian, renal and liver cancers showed weak to moderate cytoplasmic positivity.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several melanomas and gliomas displayed moderate to strong cytoplasmic positivity. Several seminomas and carcinoids along with a few urothelial cancers showed weak to moderate staining. Remaining cancer cells were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Thyroid cancers showed strong cytoplasmic immunoreactivity. Several endometrial cancers along with rare cervical, renal and ovarian cancers were moderate to strongly stained. Remaining cancer tissues were weakly stained or generally negative.

GENE INFORMATION

Gene name

AXL (HGNC Symbol)

Synonyms

ARK, JTK11, Tyro7, UFO

Description

AXL receptor tyrosine kinase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Chromosome

19

Cytoband

q13.2

Chromosome location (bp)

41219203 - 41261766

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167601 (version 83.38)

Entrez gene

558

UniProt

P30530 (UniProt - Evidence at protein level)

neXtProt

NX_P30530

Antibodypedia

AXL antibodies

PROTEIN BROWSER

AXL-001
AXL-002
AXL-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AXL-001
ENSP00000301178
ENST00000301178
P30530 [Direct mapping]
Tyrosine-protein kinase receptor UFO
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001764 [neuron migration]
GO:0001779 [natural killer cell differentiation]
GO:0001786 [phosphatidylserine binding]
GO:0001961 [positive regulation of cytokine-mediated signaling pathway]
GO:0001974 [blood vessel remodeling]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006909 [phagocytosis]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007167 [enzyme linked receptor protein signaling pathway]
GO:0007283 [spermatogenesis]
GO:0009986 [cell surface]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021885 [forebrain cell migration]
GO:0030168 [platelet activation]
GO:0031668 [cellular response to extracellular stimulus]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032825 [positive regulation of natural killer cell differentiation]
GO:0032940 [secretion by cell]
GO:0034101 [erythrocyte homeostasis]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035457 [cellular response to interferon-alpha]
GO:0042698 [ovulation cycle]
GO:0043066 [negative regulation of apoptotic process]
GO:0043277 [apoptotic cell clearance]
GO:0043491 [protein kinase B signaling]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044228 [host cell surface]
GO:0045087 [innate immune response]
GO:0046718 [viral entry into host cell]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048469 [cell maturation]
GO:0048549 [positive regulation of pinocytosis]
GO:0051250 [negative regulation of lymphocyte activation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060068 [vagina development]
GO:0070062 [extracellular exosome]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0097028 [dendritic cell differentiation]
GO:2000669 [negative regulation of dendritic cell apoptotic process]
Show all
894 aa
98.3 kDa
Yes 1
AXL-002
ENSP00000351995
ENST00000359092
P30530 [Direct mapping]
Tyrosine-protein kinase receptor UFO
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001786 [phosphatidylserine binding]
GO:0001961 [positive regulation of cytokine-mediated signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006909 [phagocytosis]
GO:0007165 [signal transduction]
GO:0009986 [cell surface]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032825 [positive regulation of natural killer cell differentiation]
GO:0035457 [cellular response to interferon-alpha]
GO:0044228 [host cell surface]
GO:0045087 [innate immune response]
GO:0046718 [viral entry into host cell]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048469 [cell maturation]
GO:0048549 [positive regulation of pinocytosis]
GO:0070062 [extracellular exosome]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0097028 [dendritic cell differentiation]
GO:2000669 [negative regulation of dendritic cell apoptotic process]
Show all
885 aa
97.4 kDa
Yes 1
AXL-004
ENSP00000471497
ENST00000593513
M0R0W6 [Direct mapping]
Receptor protein-tyrosine kinase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
626 aa
69.2 kDa
No 1

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.