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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

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Score

Score

Score

Antibodies

Column

 
 
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AXL
  • TISSUE

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

AXL

Gene description

AXL receptor tyrosine kinase

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues including testis and renal tubules.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Uncertain based on 3 antibodies.
HPA037422 , HPA037423 , CAB032501
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

AXL (HGNC Symbol)

Synonyms

ARK, JTK11, Tyro7, UFO

Description

AXL receptor tyrosine kinase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Chromosome

19

Cytoband

q13.2

Chromosome location (bp)

41219203 - 41261766

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167601 (version 83.38)

Entrez gene

558

UniProt

P30530 (UniProt - Evidence at protein level)

neXtProt

NX_P30530

Antibodypedia

AXL antibodies

PROTEIN BROWSER

AXL-001
AXL-002
AXL-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AXL-001
ENSP00000301178
ENST00000301178
P30530 [Direct mapping]
Tyrosine-protein kinase receptor UFO
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001764 [neuron migration]
GO:0001779 [natural killer cell differentiation]
GO:0001786 [phosphatidylserine binding]
GO:0001961 [positive regulation of cytokine-mediated signaling pathway]
GO:0001974 [blood vessel remodeling]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006909 [phagocytosis]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007167 [enzyme linked receptor protein signaling pathway]
GO:0007283 [spermatogenesis]
GO:0009986 [cell surface]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021885 [forebrain cell migration]
GO:0030168 [platelet activation]
GO:0031668 [cellular response to extracellular stimulus]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032825 [positive regulation of natural killer cell differentiation]
GO:0032940 [secretion by cell]
GO:0034101 [erythrocyte homeostasis]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035457 [cellular response to interferon-alpha]
GO:0042698 [ovulation cycle]
GO:0043066 [negative regulation of apoptotic process]
GO:0043277 [apoptotic cell clearance]
GO:0043491 [protein kinase B signaling]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044228 [host cell surface]
GO:0045087 [innate immune response]
GO:0046718 [viral entry into host cell]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048469 [cell maturation]
GO:0048549 [positive regulation of pinocytosis]
GO:0051250 [negative regulation of lymphocyte activation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060068 [vagina development]
GO:0070062 [extracellular exosome]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0097028 [dendritic cell differentiation]
GO:2000669 [negative regulation of dendritic cell apoptotic process]
Show all
894 aa
98.3 kDa
Yes 1
AXL-002
ENSP00000351995
ENST00000359092
P30530 [Direct mapping]
Tyrosine-protein kinase receptor UFO
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001786 [phosphatidylserine binding]
GO:0001961 [positive regulation of cytokine-mediated signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006909 [phagocytosis]
GO:0007165 [signal transduction]
GO:0009986 [cell surface]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032825 [positive regulation of natural killer cell differentiation]
GO:0035457 [cellular response to interferon-alpha]
GO:0044228 [host cell surface]
GO:0045087 [innate immune response]
GO:0046718 [viral entry into host cell]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048469 [cell maturation]
GO:0048549 [positive regulation of pinocytosis]
GO:0070062 [extracellular exosome]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0097028 [dendritic cell differentiation]
GO:2000669 [negative regulation of dendritic cell apoptotic process]
Show all
885 aa
97.4 kDa
Yes 1
AXL-004
ENSP00000471497
ENST00000593513
M0R0W6 [Direct mapping]
Receptor protein-tyrosine kinase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
626 aa
69.2 kDa
No 1

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