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Moderate to strong cytoplasmic immunoreactivity was observed in cases of gliomas, hepatocellular carcinomas, renal, prostate and cervical cancers. A few endometrial cancers showed moderate cytoplasmic and/or membranous staining. Remaining cancers were negative.
This gene encodes a member of the semaphorin family, a group of proteins characterized by the presence of a conserved semaphorin (sema) domain. Whereas some semaphorins are transmembrane proteins, others are secreted. Semaphorins play a major role in axon guidance. The protein encoded by this gene may be involved in both peripheral and central nervous system development. [provided by RefSeq, Jul 2008]