Expression of SEMA6B in cancer - Summary - The Human Protein Atlas

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SEMA6B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SEMA6B
Gene description	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
Protein class	Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (Hep G2, HMC-1, HUVEC TERT2, TIME)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in nuclear membrane of cells in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 3 antibodies. HPA055778 , HPA058523 , CAB025157
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and thyroid cancer (unfavourable).
Renal cancer p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA055778	HPA058523	CAB025157

GENE INFORMATION
Gene name	SEMA6B (HGNC Symbol)
Synonyms	SEM-SEMA-Y, SEMA-VIB, SEMAN, semaZ
Description	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the semaphorin family, a group of proteins characterized by the presence of a conserved semaphorin (sema) domain. Whereas some semaphorins are transmembrane proteins, others are secreted. Semaphorins play a major role in axon guidance. The protein encoded by this gene may be involved in both peripheral and central nervous system development. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	4542593 - 4559808
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167680 (version 83.38)
Entrez gene	10501
UniProt	Q9H3T3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H3T3
Antibodypedia	SEMA6B antibodies

PROTEIN BROWSER

SEMA6B-001	SEMA6B-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SEMA6B-001 ENSP00000467290 ENST00000586582	Q9H3T3 [Direct mapping] Semaphorin-6B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Show all	GO:0001755 [neural crest cell migration] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0016020 [membrane] GO:0030215 [semaphorin receptor binding] GO:0030335 [positive regulation of cell migration] GO:0045499 [chemorepellent activity] GO:0048843 [negative regulation of axon extension involved in axon guidance] GO:0050919 [negative chemotaxis] GO:0071526 [semaphorin-plexin signaling pathway] Show all	888 aa 95.3 kDa	Yes	1
SEMA6B-002 ENSP00000465722 ENST00000586965	Q9H3T3 [Direct mapping] Semaphorin-6B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Show all	GO:0001755 [neural crest cell migration] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0016020 [membrane] GO:0030215 [semaphorin receptor binding] GO:0030335 [positive regulation of cell migration] GO:0045499 [chemorepellent activity] GO:0048843 [negative regulation of axon extension involved in axon guidance] GO:0050919 [negative chemotaxis] GO:0071526 [semaphorin-plexin signaling pathway] Show all	677 aa 74 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.