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SEMA6B

GENERAL INFORMATION

Gene name

 SEMA6B

Gene description

 Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B

Protein class

 Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Expression in nuclear membrane of cells in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA055778 , HPA058523 , CAB025157
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SEMA6B (HGNC Symbol)

Synonyms

 SEM-SEMA-Y, SEMA-VIB, SEMAN, semaZ

Description

 Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the semaphorin family, a group of proteins characterized by the presence of a conserved semaphorin (sema) domain. Whereas some semaphorins are transmembrane proteins, others are secreted. Semaphorins play a major role in axon guidance. The protein encoded by this gene may be involved in both peripheral and central nervous system development. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 4542593 - 4559808

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167680 (version 83.38)

Entrez gene

 10501

UniProt

 Q9H3T3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H3T3

Antibodypedia

 SEMA6B antibodies

PROTEIN BROWSER
SEMA6B-001
SEMA6B-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SEMA6B-001
ENSP00000467290
ENST00000586582
Q9H3T3 [Direct mapping]
Semaphorin-6B
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Show all
GO:0001755 [neural crest cell migration]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0016020 [membrane]
GO:0030215 [semaphorin receptor binding]
GO:0030335 [positive regulation of cell migration]
GO:0045499 [chemorepellent activity]
GO:0048843 [negative regulation of axon extension involved in axon guidance]
GO:0050919 [negative chemotaxis]
GO:0071526 [semaphorin-plexin signaling pathway]
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 888 aa
95.3 kDa 		Yes 1
SEMA6B-002
ENSP00000465722
ENST00000586965
Q9H3T3 [Direct mapping]
Semaphorin-6B
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Show all
GO:0001755 [neural crest cell migration]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0016020 [membrane]
GO:0030215 [semaphorin receptor binding]
GO:0030335 [positive regulation of cell migration]
GO:0045499 [chemorepellent activity]
GO:0048843 [negative regulation of axon extension involved in axon guidance]
GO:0050919 [negative chemotaxis]
GO:0071526 [semaphorin-plexin signaling pathway]
Show all
 677 aa
74 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.