Cell atlas - BMI1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	BMI1
Gene description	BMI1 proto-oncogene, polycomb ring finger
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & nuclear bodies. In addition localized to the nucleoli & cytosol. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Nuclear bodies (approved)
Additional location	In addition localized to the Nucleoli (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA030471 , HPA030472
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & nuclear bodies. In addition localized to the nucleoli & cytosol. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleus (approved), Nuclear bodies (approved)

Additional location

Nucleoli (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA030471	HEK 293	Nuclear bodies
HPA030471	PC-3	Nuclear bodies
HPA030471	U-2 OS	Nuclear bodies
HPA030471	U-2 OS	Cytosol
HPA030472	A-431	Nucleus
HPA030472	U-2 OS	Nucleus
HPA030472	U-2 OS	Nuclear bodies
HPA030472	U-251 MG	Nucleus
HPA030472	U-251 MG	Nucleoli

GENE INFORMATION
Gene name	BMI1 (HGNC Symbol)
Synonyms	PCGF4, RNF51
Description	BMI1 proto-oncogene, polycomb ring finger (HGNC Symbol)
Entrez gene summary	This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]
Chromosome	10
Cytoband	p12.2
Chromosome location (bp)	22321211 - 22331484
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168283 (version 83.38)
Entrez gene	648
UniProt	P35226 (UniProt - Evidence at protein level)
neXtProt	NX_P35226
Antibodypedia	BMI1 antibodies

PROTEIN BROWSER

BMI1-001	BMI1-002	BMI1-005	BMI1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BMI1-001 ENSP00000365851 ENST00000376663	P35226 [Direct mapping] Polycomb complex protein BMI-1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000151 [ubiquitin ligase complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007379 [segment specification] GO:0008270 [zinc ion binding] GO:0010468 [regulation of gene expression] GO:0016568 [chromatin modification] GO:0016925 [protein sumoylation] GO:0030097 [hemopoiesis] GO:0031519 [PcG protein complex] GO:0035102 [PRC1 complex] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0046872 [metal ion binding] GO:0048146 [positive regulation of fibroblast proliferation] GO:0051443 [positive regulation of ubiquitin-protein transferase activity] GO:0071535 [RING-like zinc finger domain binding] Show all	326 aa 36.9 kDa	No	0
BMI1-002 ENSP00000397912 ENST00000442508	Q5T8Z4 [Direct mapping] Polycomb complex protein BMI-1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	150 aa 17.4 kDa	No	0
BMI1-005 ENSP00000390768 ENST00000443519	Q5T8Z2 [Direct mapping] Polycomb complex protein BMI-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	184 aa 21.3 kDa	No	0
BMI1-008 ENSP00000399220 ENST00000416820	Q5T8Z6 [Direct mapping] Polycomb complex protein BMI-1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	105 aa 12.2 kDa	No	0