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Most cancer tissues displayed weak to moderate nuclear staining. Several malignant gliomas were strongly stained. Lung and testicular cancers were negative in a majority of cases.
GENE INFORMATION
Gene name
BMI1 (HGNC Symbol)
Synonyms
PCGF4, RNF51
Description
BMI1 proto-oncogene, polycomb ring finger (HGNC Symbol)
Entrez gene summary
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]
P35226 [Direct mapping] Polycomb complex protein BMI-1
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THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)