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BMI1

GENERAL INFORMATION

Gene name

 BMI1

Gene description

 BMI1 proto-oncogene, polycomb ring finger

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA030472 , CAB011120
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Nasopharynx

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 BMI1 (HGNC Symbol)

Synonyms

 PCGF4, RNF51

Description

 BMI1 proto-oncogene, polycomb ring finger (HGNC Symbol)

Entrez gene summary

 This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]

Chromosome

 10

Cytoband

 p12.2

Chromosome location (bp)

 22321211 - 22331484

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168283 (version 83.38)

Entrez gene

 648

UniProt

 P35226 (UniProt - Evidence at protein level)

neXtProt

 NX_P35226

Antibodypedia

 BMI1 antibodies

PROTEIN BROWSER
BMI1-001
BMI1-002
BMI1-005
BMI1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BMI1-001
ENSP00000365851
ENST00000376663
P35226 [Direct mapping]
Polycomb complex protein BMI-1
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000151 [ubiquitin ligase complex]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007379 [segment specification]
GO:0008270 [zinc ion binding]
GO:0010468 [regulation of gene expression]
GO:0016568 [chromatin modification]
GO:0016925 [protein sumoylation]
GO:0030097 [hemopoiesis]
GO:0031519 [PcG protein complex]
GO:0035102 [PRC1 complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0071535 [RING-like zinc finger domain binding]
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 326 aa
36.9 kDa 		No 0
BMI1-002
ENSP00000397912
ENST00000442508
Q5T8Z4 [Direct mapping]
Polycomb complex protein BMI-1
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
GO:0046872 [metal ion binding]
Show all
 150 aa
17.4 kDa 		No 0
BMI1-005
ENSP00000390768
ENST00000443519
Q5T8Z2 [Direct mapping]
Polycomb complex protein BMI-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
GO:0046872 [metal ion binding]
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 184 aa
21.3 kDa 		No 0
BMI1-008
ENSP00000399220
ENST00000416820
Q5T8Z6 [Direct mapping]
Polycomb complex protein BMI-1
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
GO:0046872 [metal ion binding]
Show all
 105 aa
12.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.