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SCN11A

GENERAL INFORMATION

Gene name

 SCN11A

Gene description

 Sodium channel, voltage gated, type XI alpha subunit

Protein class

 Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enhanced (HDLM-2)
HPA (normal tissue):Tissue enhanced (placenta, spleen)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA036746 , HPA036747
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA036746
HPA036747

GENE INFORMATION

Gene name

 SCN11A (HGNC Symbol)

Synonyms

 NaN, Nav1.9, SCN12A, SNS-2

Description

 Sodium channel, voltage gated, type XI alpha subunit (HGNC Symbol)

Entrez gene summary

 Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.[supplied by OMIM, Apr 2004]

Chromosome

 3

Cytoband

 p22.2

Chromosome location (bp)

 38845769 - 38950561

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168356 (version 83.38)

Entrez gene

 11280

UniProt

 Q9UI33 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UI33

Antibodypedia

 SCN11A antibodies

PROTEIN BROWSER
SCN11A-001
SCN11A-002
SCN11A-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SCN11A-001
ENSP00000307599
ENST00000302328
Q9UI33 [Direct mapping]
Sodium channel protein type 11 subunit alpha
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Sodium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001518 [voltage-gated sodium channel complex]
GO:0005216 [ion channel activity]
GO:0005248 [voltage-gated sodium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006814 [sodium ion transport]
GO:0016020 [membrane]
GO:0019228 [neuronal action potential]
GO:0030424 [axon]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0042493 [response to drug]
GO:0044299 [C-fiber]
GO:0051930 [regulation of sensory perception of pain]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0086010 [membrane depolarization during action potential]
Show all
 1791 aa
204.9 kDa 		No >9
SCN11A-002
ENSP00000408028
ENST00000444237
Q9UI33 [Direct mapping]
Sodium channel protein type 11 subunit alpha
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Sodium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001518 [voltage-gated sodium channel complex]
GO:0005216 [ion channel activity]
GO:0005248 [voltage-gated sodium channel activity]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006814 [sodium ion transport]
GO:0016020 [membrane]
GO:0019228 [neuronal action potential]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0042493 [response to drug]
GO:0051930 [regulation of sensory perception of pain]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0086010 [membrane depolarization during action potential]
Show all
 1444 aa
165.7 kDa 		No >9
SCN11A-003
ENSP00000416757
ENST00000456224
Q9UI33 [Direct mapping]
Sodium channel protein type 11 subunit alpha
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Sodium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001518 [voltage-gated sodium channel complex]
GO:0005216 [ion channel activity]
GO:0005248 [voltage-gated sodium channel activity]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006814 [sodium ion transport]
GO:0016020 [membrane]
GO:0019228 [neuronal action potential]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0042493 [response to drug]
GO:0051930 [regulation of sensory perception of pain]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0086010 [membrane depolarization during action potential]
Show all
 1753 aa
200.4 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.