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POLR3D

GENERAL INFORMATION

Gene name

 POLR3D

Gene description

 Polymerase (RNA) III (DNA directed) polypeptide D, 44kDa

Protein class

 Predicted intracellular proteins
RNA polymerase related proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA067875 , HPA068461
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA067875
HPA068461

GENE INFORMATION

Gene name

 POLR3D (HGNC Symbol)

Synonyms

 BN51T, RPC4, TSBN51

Description

 Polymerase (RNA) III (DNA directed) polypeptide D, 44kDa (HGNC Symbol)

Entrez gene summary

 This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 p21.3

Chromosome location (bp)

 22245104 - 22254600

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168495 (version 83.38)

Entrez gene

 661

UniProt

 P05423 (UniProt - Evidence at protein level)

neXtProt

 NX_P05423

Antibodypedia

 POLR3D antibodies

PROTEIN BROWSER
POLR3D-001
POLR3D-003
POLR3D-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLR3D-001
ENSP00000380904
ENST00000397802
P05423 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC4
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000790 [nuclear chromatin]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0045087 [innate immune response]
GO:0045089 [positive regulation of innate immune response]
GO:0051607 [defense response to virus]
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 398 aa
44.4 kDa 		No 0
POLR3D-003
ENSP00000303088
ENST00000306433
P05423 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC4
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0045087 [innate immune response]
GO:0045089 [positive regulation of innate immune response]
GO:0051607 [defense response to virus]
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 398 aa
44.4 kDa 		No 0
POLR3D-005
ENSP00000429677
ENST00000519237
E5RHT4 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC4
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005737 [cytoplasm]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 207 aa
23.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.