Tissue expression of POLR3D - Summary - The Human Protein Atlas

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POLR3D

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TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	POLR3D
Gene description	Polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
Protein class	Predicted intracellular proteins RNA polymerase related proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous nuclear expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA067875 , HPA068461
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	POLR3D (HGNC Symbol)
Synonyms	BN51T, RPC4, TSBN51
Description	Polymerase (RNA) III (DNA directed) polypeptide D, 44kDa (HGNC Symbol)
Entrez gene summary	This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p21.3
Chromosome location (bp)	22245104 - 22254600
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168495 (version 83.38)
Entrez gene	661
UniProt	P05423 (UniProt - Evidence at protein level)
neXtProt	NX_P05423
Antibodypedia	POLR3D antibodies

PROTEIN BROWSER

POLR3D-001	POLR3D-003	POLR3D-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POLR3D-001 ENSP00000380904 ENST00000397802	P05423 [Direct mapping] DNA-directed RNA polymerase III subunit RPC4 Show all	Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0001056 [RNA polymerase III activity] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005654 [nucleoplasm] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006383 [transcription from RNA polymerase III promoter] GO:0006385 [transcription elongation from RNA polymerase III promoter] GO:0006386 [termination of RNA polymerase III transcription] GO:0010467 [gene expression] GO:0032481 [positive regulation of type I interferon production] GO:0032728 [positive regulation of interferon-beta production] GO:0045087 [innate immune response] GO:0045089 [positive regulation of innate immune response] GO:0051607 [defense response to virus] Show all	398 aa 44.4 kDa	No	0
POLR3D-003 ENSP00000303088 ENST00000306433	P05423 [Direct mapping] DNA-directed RNA polymerase III subunit RPC4 Show all	Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0001056 [RNA polymerase III activity] GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005654 [nucleoplasm] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006383 [transcription from RNA polymerase III promoter] GO:0006385 [transcription elongation from RNA polymerase III promoter] GO:0006386 [termination of RNA polymerase III transcription] GO:0010467 [gene expression] GO:0032481 [positive regulation of type I interferon production] GO:0032728 [positive regulation of interferon-beta production] GO:0045087 [innate immune response] GO:0045089 [positive regulation of innate immune response] GO:0051607 [defense response to virus] Show all	398 aa 44.4 kDa	No	0
POLR3D-005 ENSP00000429677 ENST00000519237	E5RHT4 [Direct mapping] DNA-directed RNA polymerase III subunit RPC4 Show all	Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001056 [RNA polymerase III activity] GO:0003677 [DNA binding] GO:0005654 [nucleoplasm] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005737 [cytoplasm] GO:0006383 [transcription from RNA polymerase III promoter] Show all	207 aa 23.4 kDa	No	0

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