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CTRB1

GENERAL INFORMATION

Gene name

 CTRB1

Gene description

 Chymotrypsinogen B1

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (pancreatic cancer)
HPA (cell line):Cell line enhanced (EFO-21, HDLM-2, U-2 OS)
HPA (normal tissue):Tissue enriched (pancreas)

Protein evidence

 Evidence at transcript level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (pancreatic cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CTRB1 (HGNC Symbol)

Synonyms

 CTRB

Description

 Chymotrypsinogen B1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one of a family of serine proteases that is secreted into the gastrointestinal tract as an inactive precursor, which is activated by proteolytic cleavage with trypsin. [provided by RefSeq, Oct 2011]

Chromosome

 16

Cytoband

 q23.1

Chromosome location (bp)

 75219000 - 75224924

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000168925 (version 83.38)

Entrez gene

 1504

UniProt

 P17538 (UniProt - Evidence at transcript level)

neXtProt

 NX_P17538

Antibodypedia

 CTRB1 antibodies

PROTEIN BROWSER
CTRB1-001
CTRB1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTRB1-001
ENSP00000354294
ENST00000361017
P17538 [Direct mapping]
Chymotrypsinogen B Chymotrypsin B chain A Chymotrypsin B chain B Chymotrypsin B chain C
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0004252 [serine-type endopeptidase activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0007586 [digestion]
GO:0009235 [cobalamin metabolic process]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0044281 [small molecule metabolic process]
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 263 aa
27.7 kDa 		Yes 0
CTRB1-002
ENSP00000463301
ENST00000495583
J3QKZ2 [Direct mapping]
Chymotrypsinogen B
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
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 182 aa
19.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.