Expression of DCXR in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DCXR
Gene description	Dicarbonyl/L-xylulose reductase
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Group enriched (epididymis, kidney, liver, prostate)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissue. Highest expression levels in liver, renal tubules and in epididymis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. External characterization data supports antibody staining.
Reliability score	Supported based on 2 antibodies. HPA023371 , HPA023863
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA023371	HPA023863

GENE INFORMATION
Gene name	DCXR (HGNC Symbol)
Synonyms	DCR, KIDCR, SDR20C1
Description	Dicarbonyl/L-xylulose reductase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	82035136 - 82037732
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169738 (version 83.38)
Entrez gene	51181
UniProt	Q7Z4W1 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z4W1
Antibodypedia	DCXR antibodies

PROTEIN BROWSER

DCXR-001	DCXR-006	DCXR-007	DCXR-010	DCXR-011	DCXR-015	DCXR-021

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DCXR-001 ENSP00000303356 ENST00000306869	Q7Z4W1 [Direct mapping] L-xylulose reductase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005881 [cytoplasmic microtubule] GO:0005886 [plasma membrane] GO:0005902 [microvillus] GO:0005903 [brush border] GO:0005975 [carbohydrate metabolic process] GO:0005997 [xylulose metabolic process] GO:0006006 [glucose metabolic process] GO:0006739 [NADP metabolic process] GO:0016491 [oxidoreductase activity] GO:0016614 [oxidoreductase activity, acting on CH-OH group of donors] GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor] GO:0019640 [glucuronate catabolic process to xylulose 5-phosphate] GO:0042732 [D-xylose metabolic process] GO:0044281 [small molecule metabolic process] GO:0050038 [L-xylulose reductase (NADP+) activity] GO:0051289 [protein homotetramerization] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	244 aa 25.9 kDa	No	0
DCXR-006 ENSP00000462226 ENST00000579155	J3KRZ4 [Direct mapping] L-xylulose reductase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	141 aa 14.9 kDa	No	0
DCXR-007 ENSP00000462272 ENST00000582900	J3KS22 [Direct mapping] L-xylulose reductase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	224 aa 24 kDa	No	0
DCXR-010 ENSP00000462725 ENST00000577712	J3KSZ5 [Direct mapping] L-xylulose reductase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	143 aa 15 kDa	No	0
DCXR-011 ENSP00000464507 ENST00000581584	J3QS36 [Direct mapping] L-xylulose reductase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	225 aa 23.5 kDa	No	0
DCXR-015 ENSP00000463354 ENST00000577532	J3QL34 [Direct mapping] L-xylulose reductase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	176 aa 18.9 kDa	No	0
DCXR-021 ENSP00000464332 ENST00000579004	J3QRQ2 [Direct mapping] L-xylulose reductase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		86 aa 9.2 kDa	No	0