Fields »
ABOUT
HELP
BLOG
DCXR

GENERAL INFORMATION

Gene name

 DCXR

Gene description

 Dicarbonyl/L-xylulose reductase

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (epididymis, kidney, liver, prostate)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissue. Highest expression levels in liver, renal tubules and in epididymis.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Supported based on 2 antibodies.
HPA023371 , HPA023863
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Epididymis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (epididymis, kidney, liver, prostate)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DCXR (HGNC Symbol)

Synonyms

 DCR, KIDCR, SDR20C1

Description

 Dicarbonyl/L-xylulose reductase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]

Chromosome

 17

Cytoband

 q25.3

Chromosome location (bp)

 82035136 - 82037732

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169738 (version 83.38)

Entrez gene

 51181

UniProt

 Q7Z4W1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z4W1

Antibodypedia

 DCXR antibodies

PROTEIN BROWSER
DCXR-001
DCXR-006
DCXR-007
DCXR-010
DCXR-011
DCXR-015
DCXR-021

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DCXR-001
ENSP00000303356
ENST00000306869
Q7Z4W1 [Direct mapping]
L-xylulose reductase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005903 [brush border]
GO:0005975 [carbohydrate metabolic process]
GO:0005997 [xylulose metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006739 [NADP metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016614 [oxidoreductase activity, acting on CH-OH group of donors]
GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor]
GO:0019640 [glucuronate catabolic process to xylulose 5-phosphate]
GO:0042732 [D-xylose metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050038 [L-xylulose reductase (NADP+) activity]
GO:0051289 [protein homotetramerization]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 244 aa
25.9 kDa 		No 0
DCXR-006
ENSP00000462226
ENST00000579155
J3KRZ4 [Direct mapping]
L-xylulose reductase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 141 aa
14.9 kDa 		No 0
DCXR-007
ENSP00000462272
ENST00000582900
J3KS22 [Direct mapping]
L-xylulose reductase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 224 aa
24 kDa 		No 0
DCXR-010
ENSP00000462725
ENST00000577712
J3KSZ5 [Direct mapping]
L-xylulose reductase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 143 aa
15 kDa 		No 0
DCXR-011
ENSP00000464507
ENST00000581584
J3QS36 [Direct mapping]
L-xylulose reductase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 225 aa
23.5 kDa 		No 0
DCXR-015
ENSP00000463354
ENST00000577532
J3QL34 [Direct mapping]
L-xylulose reductase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 176 aa
18.9 kDa 		No 0
DCXR-021
ENSP00000464332
ENST00000579004
J3QRQ2 [Direct mapping]
L-xylulose reductase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 86 aa
9.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.