Cell atlas - TM4SF4 - The Human Protein Atlas

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TM4SF4

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	TM4SF4
Gene description	Transmembrane 4 L six family member 4
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the cytosol.
RNA cell category	Group enriched (RPTEC TERT1, A549)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA046430
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (RPTEC TERT1, A549) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the cytosol.

Main location

Plasma membrane (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA046430	A549	Plasma membrane
	HPA046430	A549	Cytosol
	HPA046430	U-2 OS	Cytosol
	HPA046430	U-251 MG	Plasma membrane
	HPA046430	U-251 MG	Cytosol

GENE INFORMATION
Gene name	TM4SF4 (HGNC Symbol)
Synonyms	il-TMP
Description	Transmembrane 4 L six family member 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]
Chromosome	3
Cytoband	q25.1
Chromosome location (bp)	149473974 - 149503281
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169903 (version 83.38)
Entrez gene	7104
UniProt	P48230 (UniProt - Evidence at protein level)
neXtProt	NX_P48230
Antibodypedia	TM4SF4 antibodies

PROTEIN BROWSER

TM4SF4-001	TM4SF4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TM4SF4-001 ENSP00000305852 ENST00000305354	P48230 [Direct mapping] Transmembrane 4 L6 family member 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0042246 [tissue regeneration] Show all	202 aa 21.4 kDa	No	4
TM4SF4-002 ENSP00000419367 ENST00000465758	C9JVD2 [Direct mapping] Transmembrane 4 L6 family member 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	81 aa 8.5 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.