Expression of TM4SF4 in cancer - Summary - The Human Protein Atlas

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TM4SF4

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TM4SF4
Gene description	Transmembrane 4 L six family member 4
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (liver cancer, pancreatic cancer)
HPA (cell line):	Group enriched (A549, RPTEC TERT1)
HPA (normal tissue):	Group enriched (duodenum, gallbladder, liver, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression mainly in liver, gallbladder, duodenum and small intestine

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA046430
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (liver cancer, pancreatic cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046430

GENE INFORMATION
Gene name	TM4SF4 (HGNC Symbol)
Synonyms	il-TMP
Description	Transmembrane 4 L six family member 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]
Chromosome	3
Cytoband	q25.1
Chromosome location (bp)	149473974 - 149503281
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169903 (version 83.38)
Entrez gene	7104
UniProt	P48230 (UniProt - Evidence at protein level)
neXtProt	NX_P48230
Antibodypedia	TM4SF4 antibodies

PROTEIN BROWSER

TM4SF4-001	TM4SF4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TM4SF4-001 ENSP00000305852 ENST00000305354	P48230 [Direct mapping] Transmembrane 4 L6 family member 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0042246 [tissue regeneration] Show all	202 aa 21.4 kDa	No	4
TM4SF4-002 ENSP00000419367 ENST00000465758	C9JVD2 [Direct mapping] Transmembrane 4 L6 family member 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	81 aa 8.5 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.