Distinct membranous immunoreactivity was observed in liver and pancreatic cancers. Most cases of liver, pancreatic and ovarian cancers along with several colorectal, breast and prostate cancers exhibited moderate to strong cytoplasmic positivity. Remaining cancers were in general negative.
TM4SF4 (HGNC Symbol)
Transmembrane 4 L six family member 4 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]